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Purified anti-CCL11 (Eotaxin) Antibody

Pricing & Availability
Clone
L402H11 (See other available formats)
Regulatory Status
RUO
Other Names
Chemokine (C-C Motif) ligand 11, Eotaxin-1, Eosinophil chemotactic protein, Small-inducible cytokine A11
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
L402H11_Purified_CCL11_Antibody_WB_043014
Western blot analysis of 50 ng of recombinant human CCL11 (lane 1) and 50 ng of recombinant mouse CCL11 (lane 2) using anti-mouse CCL11 antibody (clone L402H11).
  • L402H11_Purified_CCL11_Antibody_WB_043014
    Western blot analysis of 50 ng of recombinant human CCL11 (lane 1) and 50 ng of recombinant mouse CCL11 (lane 2) using anti-mouse CCL11 antibody (clone L402H11).
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660402 100 µg 253 CHF
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Description

CCL11 selectively recruits eosinophils through binding to the chemokine receptor CCR3 during allergic response. CCL11 production is upregulated in response to several proimflammatory cytokines, such as IL-4, IL-13, TNF-α, and IFN-α, produced by mast cells and Th2 lymphocytes. CCL11 has been reported to stimulate eosinophil release from bone marrow, resulting in an elevated level of circulating eosinophils.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human CCL11 recombinant protein (Gly24-Pro97) expressed in E. coli.
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
Affinity purified.
Concentration
0.5 mg/ml
Storage & Handling
Upon receipt, store undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2563471 (BioLegend Cat. No. 660402)

Antigen Details

Structure
74 amino acid, predicted molecular weight of approximately 12 kD.
Distribution

Secreted. Epithelial cells, smooth muscle cells, dendritic cells, and fibroblasts.

Interaction
Eosinophils
Ligand/Receptor
CCR3
Cell Type
Dendritic cells, Eosinophils, Epithelial cells, Fibroblasts
Biology Area
Angiogenesis, Cell Biology, Immunology, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Conroy DM, et al. 2001. Respir. Res. 2:150.
2. Levina V, et al. 2009. Clin. Cancer Res. 15:2647.
3. Salcedo R, et al. 2001. J. Immunol. 166:7571.
4. Kaehler J, et al. 2006. J. Investig. Med. 54:446.
5. Hadjicharalambous C, et al. 2004. J. Allergy Clin. Immunol. 113:657.
6. Crump MP, et al. 1998. J. Biol. Chem. 273:22471.

Gene ID
6356 View all products for this Gene ID
UniProt
View information about CCL11 on UniProt.org
Go To Top Version: 3    Revision Date: 06.14.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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