- Clone
- M588 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD44, CD44 Molecule, LHR, CD44 Antigen, Cell Surface Glycoprotein CD44, CDW44
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
858801 | 25 µg | 106 CHF | ||||
858802 | 100 µg | 276 CHF |
CD44 is a cell-surface glycoprotein that is expressed in a large number of cell types. CD44 functions as an adhesion molecule that is important for cell migration and intercellular interactions and adhesion. CD44 transcripts undergo complex alternative splicing, which leads to a variety of functionally distinctive isoforms of this protein. Transcription of CD44 has been shows to be partially activated by Wnt/beta catenin signaling pathway, and thus is linked to tumor development.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC, IHC-P - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5.0 - 10 µg per mL. For immunocytochemistry, a concentration range of 5.0 - 10 μg/mL is recommended. For immunohistochemistry, a concentration range of 1 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2801225 (BioLegend Cat. No. 858801)
AB_2801225 (BioLegend Cat. No. 858802)
Antigen Details
- Structure
- CD44 is a 742 amino acid protein with an apparent molecular mass of ~ 82 kD.
- Distribution
-
Tissue distribution: Ubiquitously expressed in all tissues.
Cellular Distribution: Plasma membrane, extracellular, cytosol, and golgi apparatus. - Function
- Intercellular interaction and cell adhesion,cellular migration
- Interaction
- HA, glycosaminoglycans, collagen, laminin, fibronectin, UNC119, PDPN
- Ligand/Receptor
- Receptor for Hyaluronate
- Antigen References
-
- Price ZK, et al. 2018. Cancers (Basel). 10(12): E482
- Ouhtit A, et al. 2018. Int J Biol Sci. 14(13): 1782
- Mooney KL, et al. 2016. J Clin Neurosci. 34:1
- Gene ID
- 960 View all products for this Gene ID
- UniProt
- View information about CD44 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CD44 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-CD44 | M588 | WB,ICC,IHC-P |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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