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- Clone
- A17046B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Chitinase-like protein 3, Chil3, Beta-N-acetylhexosaminidase Ym1, Ym1, ECF-L, Eosinophil chemotactic cytokine
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Western blot of purified anti-Chil3 antibody (clone W17046B). Lane 1: Molecular weight marker; Lane 2: 20 µg of mouse spleen lysate; Lane 3: 20 µg of human spleen lysate; lane 4: 10 ng of recombinant mouse Chil3. The blot was incubated with 0.5 µg/ml of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-rat IgG (Cat. No. 405405). Cytochrome C (Cat. No. 612504) was used as loading control. Enhanced chemiluminescence was used as the detection system.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 853801 | 25 µg | 106 CHF | ||||
| 853802 | 100 µg | 276 CHF | ||||
Chitinases are hydrolytic enzymes that break down glycosidic bonds in chitin. Chitinase-like protein 3 (Chil3) hydrolyzes terminal non-reducing N-acetyl-D-hexosamine residues into N-acetyl-beta-D-hexosaminides. This protein is particular enriched in the spleen.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse Chil3
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2750120 (BioLegend Cat. No. 853801)
AB_2750120 (BioLegend Cat. No. 853802)
Antigen Details
- Structure
- Chil3 is a 398 amino acid protein with a molecular weight mass of ~45 kD.
- Distribution
-
Tissue distribution: Spleen, macrophages, and bone marrow-derived neutrophils.
Cellular distribution: Nucleus, endoplasmic reticulum, and secreted. - Function
- Chil3 plays a role in hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
- Interaction
- Chil3 binds to chitin, lectin, and heparin.
- Cell Type
- Macrophages, Neutrophils
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
- Mesci P, et al. 2015. Brain. 138:53-68
- Wu F, et al. 2016. Parasitol Res. 115:3737
- Al-Rubaie A, et al. 2018. Respir Res. 19:114
- Gene ID
- 12655 View all products for this Gene ID
- UniProt
- View information about Chil3 on UniProt.org
Other Formats
View All Chil3 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-Chil3 | A17046B | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-Chil3
Western blot of purified anti-Chil3 antibody (clone W17046B)...
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