- Clone
- Poly6563 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Epidermal growth factor receptor, HER1
- Isotype
- Rabbit Polyclonal IgG
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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656302 | 200 µL | 411 CHF |
EGFR is a transmembrane glycoprotein that belongs to protein kinase superfamily. It is expressed in tissues of epithelial, mesenchymal and neuronal origin and plays major roles in proliferation, differentiation and development. Binding of the protein to its ligand induces receptor dimerization and tyrosine autophosphorylation. Mutations or over-expression of this gene are associated with certain forms of cancer. Tyrosine 1068 is the primary autophosphorylation site in the C-terminal domain of the receptor.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Polyclonal
- Host Species
- Rabbit
- Immunogen
- KLH conjugated modified synthetic peptide
- Formulation
- Phosphate-buffered solution/50% glycerol/0.09% sodium azide.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- Upon receipt, store undiluted at -20°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5-10 µl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This product may contain other non-IgG subtypes. - RRID
-
AB_2562283 (BioLegend Cat. No. 656302)
Antigen Details
- Structure
- Four isoforms with 405 to 1210 amino acids, predicted molecular weight 45- 170 kD
- Distribution
-
Cell membrane, nuclear membrane and cellular organelle membrane
- Interaction
- Interacts with EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Activates RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.
- Biology Area
- Angiogenesis, Cell Biology, Cell Cycle/DNA Replication, DNA Repair/Replication, Immunology, Neuroscience, Signal Transduction, Synaptic Biology
- Molecular Family
- CD Molecules, Growth Factors, Phospho-Proteins, Protein Kinases/Phosphatase
- Antigen References
-
1. Alameddine RS, et al. 2013. Curr. Opin. Oncol. 25:313.
2. Downward J, et al. 2003. Anticancer Res. 23:3639.
3. Hrustanovic G, et al. 2013. Cancer Biol. Ther. 14:304.
4. Koland JG, et al. 1990. Biochem. Biophys. Res. Commun. 166:90.
5. Wheeler SE, et al. 2012. Clin. Cancer Res. 18:2278.
6. Yano S, et al. 2003. Anticancer Res. 23:3639. - Gene ID
- 1956 View all products for this Gene ID
- UniProt
- View information about EGFR on UniProt.org
Related FAQs
Other Formats
View All EGFR Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-EGFR Phosphorylated (Tyr1068) | Poly6563 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-EGFR Phosphorylated (Tyr1068)
Hela cells were starved for 16 hours and treated with (lane ...
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