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Purified anti-HIV TAT Antibody (Previously Covance catalog# MMS-116P)

Pricing & Availability
Clone
AC11.AE12 (See other available formats)
Regulatory Status
RUO
Other Names
HIV TAT
Previously
Covance Catalog# MMS-116P
Isotype
Mouse IgG1
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Product Citations
publications
AC11.AE12_Purified_HIV_TAT_Antibody_WB_031615
Western blot analysis of recombinant HIV-TAT protein. Lane 1: MW Marker; Lane 2: 50ng of protein; Lane 3: 100ng of protein.
  • AC11.AE12_Purified_HIV_TAT_Antibody_WB_031615
    Western blot analysis of recombinant HIV-TAT protein. Lane 1: MW Marker; Lane 2: 50ng of protein; Lane 3: 100ng of protein.
Cat # Size Price Quantity Check Availability Save
919001 250 µL 375 CHF
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Description

The HIV-1 TAT (transactivator of transcription) gene codes for a 14 kD protein and is vital for HIV-1 transcription. After infection, TAT is one of the first proteins expressed after HIV has taken over the host’s machinery. TAT is a RNA binding protein that recognizes the TAR (Transactivator Response Element) sequence found in the HIV-1 RNA molecule. It is also needed for the recruitment of the host positive transcription elongation factor b (p-TEFb). In neuron cells, TAT has been linked to progressive neuronal deregulation, HIV-Associated Neurocognitive Disorders and accelerating brain aging.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
HIV
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This antibody was generated against full-length HIV TAT protein.
Formulation
Phosphate-buffered solution + 0.03% Thimerosal.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

WB
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting.

The optimal working dilution should be determined for each specific assay condition.
• WB: 1:1,000*

Application Notes

This antibody is effective in immunoblotting (WB).

*Predicted MW = 11 kD

The epitope is contained in the first 37 amino acids of the protein. 

Product Citations
  1. Hategan A, et al. 2017. Nat Struct Mol Biol. 10.1038/nsmb.3379. PubMed
RRID
AB_2565207 (BioLegend Cat. No. 919001)

Antigen Details

Biology Area
Bacterial proteins and Toxins, Cell Biology
Gene ID
155871 View all products for this Gene ID
UniProt
View information about HIV TAT on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 4    Revision Date: 09.20.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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