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Purified anti-human CD141 (Thrombomodulin) Antibody

Pricing & Availability
Clone
M80 (See other available formats)
Regulatory Status
RUO
Other Names
Thrombomodulin, TM, THRM, THBD, Fetomodulin, BDCA-3
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
A_M80_PE_091509
Human peripheral blood monocytes stained with M80 PE
  • A_M80_PE_091509
    Human peripheral blood monocytes stained with M80 PE
  • B_M80_PE_090309
    LPS-stimulated (overnight) human peripheral blood mononuclear cells stained with M80 PE (gated on CD14+ cells)
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344102 100 µg 129 CHF
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Description

CD141 is a 75 kD, single chain, type I membrane glycoprotein also known as thrombomodulin, TM, THRM, THBD, and fetomodulin. CD141 is an important cofactor in the protein C anticoagulant system. After binding to its ligand thrombin, CD141 activates protein C, which degrades clotting factors Va and VIIIa, and as a consequence the amount of thrombin is reduced. CD141 is expressed on macrophages, monocytes, a subpopulation of myeloid dendritic cells, vascular endothelial cells, and keratinocytes. Besides anti-coagulation function, CD141 is also involved in embryonic and atherosclerotic plaque development. 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Friebel E, et al. 2020. Cell. 181(7):1626-1642.e20. PubMed
  2. Sullivan KD, et al. 2021. Cell Reports. 36(7):109527. PubMed
  3. Kremenovic M, et al. 2020. Cancers (Basel). 12:. PubMed
  4. Li Y, et al. 2019. Front Immunol. 0.460416667. PubMed
  5. Martin JC, et al. 2020. Cell. 178(6):1493-1508.e20.. PubMed
  6. Michlmayr D, et al. 2020. Cell Reports. 31(4):107569. PubMed
  7. Borges TJ, et al. 2018. Nat Commun. 9:3482. PubMed
  8. Galbraith MD, et al. 2021. eLife. 10:00. PubMed
  9. NULL, et al. 2022. Cell. 185:916. PubMed
  10. Chevrier S, et al. 2021. Cell Reports Medicine. 2(1):100166. PubMed
  11. Waugh KA, et al. 2020. Cell Reports. 29(7):1893-1908.e4.. PubMed
  12. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
RRID
AB_2201808 (BioLegend Cat. No. 344102)

Antigen Details

Structure
Single chain, type I membrane glycoprotein, 75 kD
Distribution

Macrophages, monocytes, subset of myeloid dendritic cells, vascular endothelial cells, keratinocytes

Function
After thrombin binding, CD141 activates protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated.
Interaction
Protein C, Thrombin-activatable fibrinolysis inhibitor (TAFI), Platelet factor 4 (PF4)
Ligand/Receptor
Thrombin
Cell Type
Dendritic cells, Endothelial cells, Macrophages, Monocytes
Biology Area
Immunology, Innate Immunity
Molecular Family
CD Molecules
Antigen References

1. Suzuki K, et al. 1987. EMBO J. 6:1891.
2. Esmon CT, et al. 1989. J. Biol. Chem. 264:4743.
3. Delvaeye M, et al. 2009. N. Engl. J. Med. 361:345.
4. Shi CS, et al. 2008. Blood 112:3661.
5. Chen LC, et al. 2009. J. Infect. 58:368.

Gene ID
7056 View all products for this Gene ID
UniProt
View information about CD141 on UniProt.org
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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