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Purified anti-human CD213a2 (IL13Rα2) Antibody

Pricing & Availability
Clone
SHM38 (See other available formats)
Regulatory Status
RUO
Other Names
CD213a2, IL-13RA2, IL-13R, IL13BP, CT19
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
SHM38_Purified_CD213a2_Antibody_FC_082412
Human melanoma cell line, A375, was stained with purified CD213a2 (clone SHM38, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
  • SHM38_Purified_CD213a2_Antibody_FC_082412
    Human melanoma cell line, A375, was stained with purified CD213a2 (clone SHM38, filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
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354401 25 µg 112 CHF
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354402 100 µg 288 CHF
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Description

CD213a2, also known as IL-13Rα2, is a type I transmembrane protein and member of the hematopoietin family. IL13Ra2 is the high affinity receptor for IL-13, but it possibly acts as a decoy receptor to antagonize IL-13Rα1/IL-4Ra-mediated IL-13 biological functions. IL13Rα2 is expressed by fibroblasts, smooth muscle cells, keratinocytes and activated B cells. However, its presence on the cell surface is highly regulated. CD213a2 is also expressed in various types of cancer which makes it an attractive therapeutic target.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Melanoma cell line A375
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Takenouchi M, et al. 2011. Clin. Cancer Res. 17:2819. (FC)
RRID
AB_2561520 (BioLegend Cat. No. 354401)
AB_2561520 (BioLegend Cat. No. 354402)

Antigen Details

Structure
Member of the hematopoietin family, type I transmembrane protein, contains 1 fibronectin type III domain
Distribution

Fibroblasts, smooth muscle cells, keratinocytes, activated B cells

Function
Possible decoy receptor, antagonist of CD213a1, internalization of IL-13
Ligand/Receptor
IL-13
Cell Type
B cells, Fibroblasts
Biology Area
Cell Biology, Immunology, Transcription Factors
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Mitchell J, et al. 2010. Curr. Opin. Investig Drugs. 11:527.
2. Strober W, et al. 2009. Curr. Mol. Med. 9:740.
3. Tabata Y, et al. 2007. Curr. Allergy Asthma Rep. 7:338.

Gene ID
3598 View all products for this Gene ID
UniProt
View information about CD213a2 on UniProt.org
Go To Top Version: 2    Revision Date: 08.31.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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