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Purified anti-human CD252 (OX40L) Antibody

Pricing & Availability
Clone
W20047C (See other available formats)
Regulatory Status
RUO
Other Names
Gp34, OX40L, CD134L, CD252, TNFSF4
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
W20047C_PURE_CD252_FC_092523
Human endothelial cells (HUVEC) were stained with purified anti-human CD252 (OX40L) (clone W20047C) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram) followed by goat anti-rat IgG PE.
  • W20047C_PURE_CD252_FC_092523
    Human endothelial cells (HUVEC) were stained with purified anti-human CD252 (OX40L) (clone W20047C) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram) followed by goat anti-rat IgG PE.
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389202 100 µg 125 CHF
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Description

OX40 ligand (OX40L), also known as gp34, CD252, CD134L or TNFSF4, is a 35 kD type II transmembrane protein which belongs to TNF superfamily. The OX40 ligand is expressed on activated B cells, activated endothelial cells, mature dendritic cells, activated CTLs, activated mast cells, and airway smooth muscle cells. OX40 ligand interacts with OX40 antigen (CD134) expressed predominantly on activated T cells to regulate T cell proliferation and differentiation, and to enhance immunoglobulin secretion by activated B cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Recombinant human OX40L protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_3083202 (BioLegend Cat. No. 389202)

Antigen Details

Structure
NGF/TNF superfamily, 35 kD
Distribution

Activated B cells, activated endothelial cells, mature dendritic cells, airway smooth muscle cells

Function
T-cell interaction, costimulation
Ligand/Receptor
OX40 (CD134)
Cell Type
B cells, Dendritic cells, Endothelial cells
Biology Area
Costimulatory Molecules, Immunology
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Antigen References
  1. Imura A, et al. 1996. J Exp Med. 183:2185-95.
  2. Ohshima Y, et al. 1997. J Immunol. 159:3838-48.
  3. Ito T, et al. 2005. J Exp Med. 202:1213-23.
  4. Ito T, et al. 2006. Proc Natl Acad.Sci. USA. 103:13138.
Gene ID
7292 View all products for this Gene ID
UniProt
View information about CD252 on UniProt.org
Go To Top Version: 1    Revision Date: 09.26.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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