- Clone
- QA17A18 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- S152, T14, TNFRSF7
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
![QA17A18_PURE_CD27_Antibody_060818 QA17A18_PURE_CD27_Antibody_060818](https://d1spbj2x7qk4bg.cloudfront.net/Admin/Public/GetImage.ashx?Image=/Files/Images/media_assets/products/product_images/QA17A18_PURE_CD27_Antibody_060818.png&Width=240&Height=300&altFmImage_path=&Compression=90&Crop=5)
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Human peripheral blood lymphocytes were stained with CD3 (clone HIT3a) Alexa Fluor® 647 and purified CD27 (clone QA17A18) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG1 PE.
Cat # | Size | Price | Quantity Check Availability | Save | ||
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393202 | 100 µg | 112 CHF |
CD27 is a 50-55 kD type I membrane protein also known as S152 and T14. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70, and plays a role in costimulation of T cell activation and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK/JNK activation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.03 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA17A18 does not block clones 0323, M-T271, or LG.3A10, indicating a unique epitope.
- RRID
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AB_2734458 (BioLegend Cat. No. 393202)
Antigen Details
- Structure
- TNF-R superfamily, type I transmembrane glycoprotein.
- Distribution
-
Medullary thymocytes, T and B cell subsets, NK cells.
- Ligand/Receptor
- CD70
- Cell Type
- B cells, NK cells, T cells, Thymocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules, TCRs
- Antigen References
-
- Knapp W, et al. 1989. Immunol. Today 10:253-8
- Schlossman S, et al. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press.
- Hintzen R, et al. 1994. Immunol. Today 15:307.
- Agematsu K, et al. 1995. J. Immunol. 154:3627.
- Gene ID
- 939 View all products for this Gene ID
- UniProt
- View information about CD27 on UniProt.org
Related FAQs
Other Formats
View All CD27 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD27 Recombinant Antibody | QA17A18 | FC |
Alexa Fluor® 647 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
PerCP/Cyanine5.5 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
PE/Cyanine7 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
Alexa Fluor® 488 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
PE anti-human CD27 Recombinant Antibody | QA17A18 | FC |
APC/Fire™ 810 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
Spark YG™ 581 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
Spark Red™ 718 anti-human CD27 Recombinant Antibody | QA17A18 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 (cl... -
Alexa Fluor® 647 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 FIT... -
PerCP/Cyanine5.5 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with True-St... -
PE/Cyanine7 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with True-St... -
Alexa Fluor® 488 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 Ale... -
PE anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 APC... -
APC/Fire™ 810 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with CD3 FIT... -
Spark YG™ 581 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu... -
Spark Red™ 718 anti-human CD27 Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu...
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