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Purified anti-human CD334 (FGFR4) Antibody

Pricing & Availability
Clone
4FR6D3 (See other available formats)
Regulatory Status
RUO
Other Names
FGFR4, fibroblast growth factor receptor 4, TKF, FGF R4
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
4FR6D3_Purified_072307
Human FGFR4 transfected NIH/3T3 cells stained with purified 4FR6D3, followed by anti-mouse IgG FITC
  • 4FR6D3_Purified_072307
    Human FGFR4 transfected NIH/3T3 cells stained with purified 4FR6D3, followed by anti-mouse IgG FITC
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324302 100 µg 206 CHF
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Description

The 4FR6D3 antibody recognizes human CD334, also known as fibroblast growth factor 4, FGFR4 and TKF. CD334 is a member of the fibroblast growth factor receptor family and a cell surface tyrosine kinase containing three immunoglobulin-like domains. FGFR4 has a predicted molecular weight of approximately 88 kD and is widely expressed in many tissues including the intestine, muscle, heart, cornea, retina, and pancreas, with highest expression in lung and kidney.CD334 binds acidic fibroblast growth factors (FGF8, GFG1, FGF19, FGF6, and FGF2); ligand binding induces mitogenesis and differentiation. CD334 has been shown to interact with STAT1 and STAT3 and is over-expressed in gynecological tumors suggesting a possible role for this receptor in breast and ovarian tumorigenesis. Unique alleles (Arg388) in FGFR4 have been shown to be associated with cancer progression and increased tumor cell motility. The 4FR6D3 antibody has been shown to be useful for flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
NIH-3T3 cells transfected with full-length human FGFR4
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
ICC - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Bussolati B, et al. 2012. Am J Physiol Renal Physiol. 302:116. PubMed.
Product Citations
  1. Bussolati B, et al. 2012. Am J Physiol Renal Physiol. 302:F116. PubMed
RRID
AB_756088 (BioLegend Cat. No. 324302)

Antigen Details

Structure
Member of the fibroblast growth factor receptor family. Cell surface tyrosine kinase containing three immunoglobulin-like domains. Predicted molecular weight approximately 88 kD.
Distribution

Widely expressed in many tissues including the intestine, muscle, heart, cornea, retina, and pancreas; highest expression in lung and kidney

Function
Ligand binding induces mitogenesis and differentiation; over-expressed in gynecological tumors suggesting a possible role for this receptor in breast and ovarian tumorigenesis. Unique alleles (Arg388) in FGFR4 have been associated with cancer progression
Interaction
STAT1, STAT3
Ligand/Receptor
Binds acidic fibroblast growth factors (FGF8, GFG1, FGF19, FGF6, and FGF2)
Cell Type
Neural Stem Cells
Biology Area
Angiogenesis, Cell Biology, Immunology, Neuroscience, Neuroscience Cell Markers, Stem Cells, Synaptic Biology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Holtrich U, et al. 1991. Proc. Natl. Acad. Sci. USA 88:10411.
2. Partanen J, et al. 1991. EMBO J. 10:1347.
3. Bange J, et al. 2002. Cancer Res. 62:840.
4. Vainikka S, et al. 1992. EMBO J. 11:4273.

Gene ID
2264 View all products for this Gene ID
UniProt
View information about CD334 on UniProt.org
Go To Top Version: 2    Revision Date: 01.14.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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