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Purified anti-human CD367 (CLEC4A) Antibody

Pricing & Availability
Clone
9E8 (See other available formats)
Regulatory Status
RUO
Workshop
HCDM listed
Other Names
DCIR, LLIR, CLECSF6, CD367
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
9E8_Purified_CLEC4A_Antibody_FC_083112
Human monocyte-derived dendritic cells were stained with purified anti-human CD367 (CLEC4A, clone 9E8) (filled histogram) or mouse IgG1, κ isotype control (open histogram) followed by biotinylated anti-mouse IgG and Sav-PE.
  • 9E8_Purified_CLEC4A_Antibody_FC_083112
    Human monocyte-derived dendritic cells were stained with purified anti-human CD367 (CLEC4A, clone 9E8) (filled histogram) or mouse IgG1, κ isotype control (open histogram) followed by biotinylated anti-mouse IgG and Sav-PE.
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355302 100 µg 206 CHF
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Description

CD367 (CLEC4A), also known as lectin-like immunoreceptor (LLIR) and dendritic cell immunoreceptor (DCIR), is a type II transmembrane protein belonging to C-type lectin domain family, and was previously designated as CLECSF6. It contains one carbohydrate recognition domain in its C-terminal extracellular domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain.  CLEC4A is mainly expressed on monocytes, macrophages, dendritic cells, neutrophils, and B cells. It is also found on the surface of CD4+ T cells in rheumatoid arthritis (RA) patients. CLEC4A has been reported to function as a receptor for HIV, cross-present and cross-prime human CD8+ T cells. It might also function as a negative player by recruiting the SHP-1 or/and SHP-2 phosphotase through its immunoreceptor tyrosine-based inhibitory motif (ITIM). 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ectodomain of CLEC4A-human Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2561529 (BioLegend Cat. No. 355302)

Antigen Details

Structure
Type II transmembrane protein with single C-type lectin domain, contain immunoreceptor tyrosine-based inhibitory motif (ITIM)
Distribution

Neturophils, monocytes, dendritic cells and B cells

Function
Receptor for HIV, cross-presentation and cross-priming of human CD8+ T cells, inhibit intracellular signaling
Cell Type
Neutrophils, Monocytes, Dendritic cells, B cells
Biology Area
Cell Biology, Immunology, Innate Immunity, Signal Transduction, Costimulatory Molecules
Molecular Family
CD Molecules, Protein Kinases/Phosphatase
Antigen References

1. Lambert AA, et al. 2011. Blood 117:6589.
2. Klechevsky E, et al. 2010. Blood 116:1685.
3. Kanazawa N, et al. 2002. J. Invest Dermatol. 118:261.
4. Voehringer D, et al. 2001. J. Immunol. 167:4838.

Gene ID
50856 View all products for this Gene ID
UniProt
View information about CLEC4A on UniProt.org
Go To Top Version: 2    Revision Date: 01.14.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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