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Purified anti-human CTAG1B Antibody

Pricing & Availability
Clone
W19067B (See other available formats)
Regulatory Status
RUO
Other Names
CT6.1, CTAG, CTAG1, ESO1, LAGE2A, LAGE2B, NY-ESO-1
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
W19067B_PURE_CTAG1B_Antibody_031522
U266 cells were fixed and permeabilized with Cyto-Fast™ Fix/Perm Buffer Set (Cat. No. 426803) and intracellularly stained with purified anti-human CTAG1B (clone W19067B) (filled histogram) or rat IgG2b, κ isotype control (open histogram) followed by PE anti-rat IgG.
  • W19067B_PURE_CTAG1B_Antibody_031522
    U266 cells were fixed and permeabilized with Cyto-Fast™ Fix/Perm Buffer Set (Cat. No. 426803) and intracellularly stained with purified anti-human CTAG1B (clone W19067B) (filled histogram) or rat IgG2b, κ isotype control (open histogram) followed by PE anti-rat IgG.
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382302 100 µg 422 CHF
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Description

Cancer/testis antigen 1 also known as LAGE2 or LAGE2B is a protein that in humans is encoded by the CTAG1B gene. It is most often referenced by its alias New York esophageal squamous cell carcinoma 1(NY-ESO-1). Cancer/Testis Antigen 1B is a protein belonging to the family of Cancer Testis Antigens (CTA) that are expressed in a variety of malignant tumors at the mRNA and protein levels, but also restricted to testicular germ cells in normal adult tissues. The protein encoded by this gene is an antigen that is overexpressed in many cancers but it is also expressed in normal testis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
hNY-ESO-1 protein (expressed by E. Coli)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2922615 (BioLegend Cat. No. 382302)

Antigen Details

Structure
CTAG1B is 180 amino acid long protein of 18 kD, containing epitopes of humoral and cellular responses in its glycine rich N terminal region and an extremely hydrophobic C terminal region.
Distribution

Normal expression is restricted to germ cells of the testis, ovary, and trophoblast cells of the placenta and upregulated in a variety of malignant tumors

Function
CTAG1B elicit both humoral and cellular immune responses in patients with cancer and therefore is a high priority target for cancer vaccine development and adoptive T-cell therapies.
Molecular Family
Protein Modifiers
Antigen References
  1. Chen, Y.T. et al. 1997. Proc Natl Acad Sci USA 94:1914-8.
  2. De Smet, C. et al. 1999. Mol Cell Biol 19:7327-35.
  3. Gnjatic, S. et al. 2006. Adv Cancer Res 95:1-30.
  4. Caballero, O.L. et al. 2009. Cancer Sci 100:2014-21.
  5. Gjerstorff, M.F. et al. 2015. Oncotarget 6:15772-87.
  6. Esfandiary, A. et al. 2015. Immunotherapy 7:411-39.
Gene ID
1485 View all products for this Gene ID
UniProt
View information about CTAG1B on UniProt.org
Go To Top Version: 1    Revision Date: 03.14.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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