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- Clone
- MHD4-46 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Delta4, Drosophila Delta homolog 4
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human DLL4 transfected CHO cells stained with MHD4-46 PE
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 346501 | 25 µg | 71 CHF | ||||
| 346502 | 100 µg | 141 CHF | ||||
Delta-like protein 4 (DLL4) is a type I transmembrane protein whose extracellular domain contains a DSL domain and eight tandem EGF repeats. After binding of its ligands Notch 1 and Notch 4, the extracellular and cytoplasmic domains are cleaved and the cytoplasmic domain is translocated into the nucleus. DLL4 is expressed in the vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes. It is also highly expressed in some types of bladder, breast, and renal carcinomas. DLL4 is critical in vascular development and homeostasis.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human DLL4
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
- Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications for the relevant formats include: blocking of DLL4 binding to Notch 1 and Notch 4.
-
Application References
(PubMed link indicates BioLegend citation) -
- Yamanda S, et al. 2009. Blood 113:3631.
- RRID
-
AB_1967111 (BioLegend Cat. No. 346501)
AB_1967111 (BioLegend Cat. No. 346502)
Antigen Details
- Structure
- Type I transmembrane protein whose extracellular domain contains a DSL domain and eight tandem EGF repeats
- Distribution
- Vascular endothelium, neural epithelium, adrenal cortex, spleen, and lymph nodes; highly expressed in some types of bladder, breast and renal carcinomas
- Function
- Vascular development and homeostasis
- Ligand/Receptor
- Notch 1 and Notch 4
- Cell Type
- Epithelial cells, Endothelial cells, Dendritic cells, Tregs
- Biology Area
- Angiogenesis, Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules
- Antigen References
-
1. Beck RC, et al. 2009. Biol Blood Marrow Transplant. 15:1026.
2. Mazella J, et al. 2008. Endocrinology. 149:15.
3. Noguera-Troise I, et al. 2006. Nature 444:1032.
4. Sugimoto A, et al. 2006. Exp Hematol. 34:424.
5. Liu ZJ, et al. 2003. Mol Cell Biol. 23:14. - Gene ID
- 54567 View all products for this Gene ID
- UniProt
- View information about DLL4 on UniProt.org
Related FAQs
Other Formats
View All DLL4 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human Delta-like protein 4 (DLL4) | MHD4-46 | FC |
| PE anti-human Delta-like protein 4 (DLL4) | MHD4-46 | FC |
| APC anti-human Delta-like protein 4 (DLL4) | MHD4-46 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human Delta-like protein 4 (DLL4)
Human DLL4 transfected CHO cells stained with MHD4-46 PE -
PE anti-human Delta-like protein 4 (DLL4)
Human DLL4 transfected CHO cells stained with MHD4-46 PE -
APC anti-human Delta-like protein 4 (DLL4)
Human DLL4-transfected CHO cells were stained with DLL4 (clo...
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