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Purified anti-human IL-17A Recombinant Antibody

Pricing & Availability
Clone
QA18A46 (See other available formats)
Regulatory Status
RUO
Other Names
Interluekin 17A, IL-17, CTLA8
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA18A46_PURE_IL-17A_Antibody_031023
Human peripheral blood lymphocytes were stimulated with Cell Activation Cocktail (with Brefeldin A) (Cat. No. 423304). Cells were surface stained with anti-human CD3 APC, then fixed, permeabilized, and intracellularly stained with purified anti-human IL-17A recombinant (clone QA18A46) (left) or purified mouse IgG1, κ isotype control (right) followed by PE rat anti-mouse IgG1 antibody.
  • QA18A46_PURE_IL-17A_Antibody_031023
    Human peripheral blood lymphocytes were stimulated with Cell Activation Cocktail (with Brefeldin A) (Cat. No. 423304). Cells were surface stained with anti-human CD3 APC, then fixed, permeabilized, and intracellularly stained with purified anti-human IL-17A recombinant (clone QA18A46) (left) or purified mouse IgG1, κ isotype control (right) followed by PE rat anti-mouse IgG1 antibody.
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385902 100 µg 248 CHF
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Description

IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A is the signature cytokine of Th17 subpopulation of CD4+ T cells. Neutrophils are also a major source of IL-17A. IL-17A can elicit multiple biological activities on a variety of cells. For instance, IL-17A can induce IL-6, IL-8, G-CSF, and PGE2 production from epithelial cells, endothelial cells, or fibroblast. IL-17A also further regulates neutrophil functions. Human IL-17A shares 63%, 63% and 72% amino acid sequence similarity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS) respectively.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ICFC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.06 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone QA18A46 can completely block the binding of clone BL168 on target cells.

RRID
AB_2936662 (BioLegend Cat. No. 385902)

Antigen Details

Structure
~15 kD cytokine
Distribution

Activated T cells, neutrophils

Function
Proinflammatory cytokine
Ligand/Receptor
IL-17A receptor
Cell Type
Lymphocytes, Neutrophils, T cells, Th17
Biology Area
Adaptive Immunity, Immunology, Innate Immunity
Molecular Family
Cytokines/Chemokines
Antigen References
  1. Spriggs MK. 1997. J Clin Immunol. 17:366-9.
  2. Kawaguchi M, et al. 2004. J Allergy Clin Immunol. 114:1265-73.
  3. Furuzawa-Carballeda J, et al. 2007. Autoimmun Rev. 6:169-75.
Gene ID
3605 View all products for this Gene ID
UniProt
View information about IL-17A on UniProt.org
Go To Top Version: 1    Revision Date: 03.10.2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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