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Purified anti-human PlGF Antibody

Pricing & Availability
Clone
13C8 (See other available formats)
Regulatory Status
RUO
Other Names
PlGF, PLGF, Placental Growth Factor
Isotype
Mouse IgG1, λ
Ave. Rating
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Product Citations
publications
13C8_Pure_PIGF_Antibody_121418
  • 13C8_Pure_PIGF_Antibody_121418
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534802 500 µg 581 CHF
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Description

Placental growth factor (PlGF) is a member of the PDGF/VEGF family of growth factors. Four alternatively-spliced isoforms have been identified: PlGF-1, PlGF-2, PlGF-3, and PlGF-4. All isoforms are expressed in placental tissues, with PlGF-2 being expressed specifically during early placental development. PlGF-1 and PlGF-3 are considered diffusible isoforms, while PlGF-2 and PlGF-4 each contain a unique heparin binding domain that may increase associations with cell membranes. In addition to placental tissues, PlGF is expressed in the microvasculature, bone marrow, umbilical vein endothelia, uterine keratinocytes, and NK cells. PlGF binds to both VEGF-R1 and neuropilin, but not VEGF-R2 and induces monocyte activation, migration, inflammatory cytokine production. PlGF plays a key role in maternal vascular function during pregnancy, with circulating levels reaching a peak mid-gestation. It can be used as a marker for pregnancy-associated hypertensive disorders such as pre-eclampsia.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant Protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA-C - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. For ELISA Capture applications, a concentration range of 1.0 - 4.0 µg/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

The purified 13C8 antibody is useful as the capture antibody in a sandwich ELISA assay, when used in conjunction with the biotinylated 24G3 antibody (Cat. No. 534904) as the detecting antibody.

RRID
AB_2894608 (BioLegend Cat. No. 534802)

Antigen Details

Structure
Homodimer
Distribution

Vascular endothelial cells, smooth muscle cells, keratinocytes, hematopoitic cells, retinal pigment epithelial cells, tumor cells, and cerebellar stroma cells.

Function
PlGF is an angiogenic factor and induces proliferation and migration of endothelial cells. It stimulates endothelial cells and synergistically amplifies the action of VEGF. Soluble VEGFR1 (sFLT1) can regulate the accessibility of PlGF.
Interaction
Endothelial cells, Macrophages, and trophoblats
Ligand/Receptor
VEGFR1 (FLT-1) and neuropilin 1 (Nrp1)
Cell Type
Endothelial cells, Epithelial cells, Hematopoietic stem and progenitors
Antigen References
  1. Maglione D, et al. 1991. Proc Natl Acad Sci USA. 88:9267.
  2. Carmeliet P, et al. 2001. Nat Med. 7:575.
  3. Casalou C, et al. 2007. Leukemia. 21:1590.
  4. Marcellini M, et al. 2006. Am J Pathol. 169:643.
  5. Yao J, et al. 2011. Proc Natl Acad Sci USA. 108:11590.
  6. Cai J, et al. 2011. PLoS One. 6:e18076.
  7. Sibiude J, et al. 2012. PLoS One. 7:e50208.
  8. Snuderl M, et al. 2013. Cell. 152:1065.
Gene ID
5228 View all products for this Gene ID
UniProt
View information about PlGF on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 12.14.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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  • Purified anti-human PlGF

    13C8_Pure_PIGF_Antibody_121418
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