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Purified anti-human TCR Vβ5 Antibody

Pricing & Availability
Clone
MH3-2 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor V beta 5
Isotype
Mouse IgG2a, κ
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Product Citations
publications
MH3-2_AF647_072110
Human peripheral blood lymphocytes stained with purified MH3-2 conjugated with Alexa Fluor® 647 and CD3 PE
  • MH3-2_AF647_072110
    Human peripheral blood lymphocytes stained with purified MH3-2 conjugated with Alexa Fluor® 647 and CD3 PE
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349301 25 µg 106 CHF
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Description

Vβ5 T cell receptor (TCR Vβ5) is a variant of the TCR β chain which is heterodimerized with TCR α chain and expressed on a subset of αβ+ T cells. TCR α/β recognizes peptides presented by the MHC molecules and initiates T cell mediated immune responses. Patients with multiple sclerosis present an expansion of Vβ5.2+/5.3+ autoreactive T cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Pigtailed Macaque
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Labrecque N, et al. 1993. J. Exp. Med. 177:1735. (FC)
  2. Oh S, et al. 2004. Cancer Res. 64:2610. (FC)
  3. Wilson JDK, et al. 1998. Eur. J. Immunol. 28:1172. (FC)
  4. Patel MR, et al. 2010. Cancer Res. 70:10141. PubMed
  5. Han JA, et al. 2014. Nanomedicine. 10:561. PubMed
Product Citations
  1. Patel M, et al. 2010. Cancer Res. 70:10141. PubMed
  2. Li F, et al. 2022. Nat Commun. 13:4334. PubMed
  3. Han J, et al. 2014. Nanomedicine. 10:561. PubMed
RRID
AB_10643416 (BioLegend Cat. No. 349301)

Antigen Details

Structure
Immunoglobulin superfamily, associates with TCR Vα chain and CD3 complex
Distribution

Subset of TCR αβ+ T cells

Function
Recognition of peptides presented by MHC molecules, responsible for T cell mediated immune response
Ligand/Receptor
MHC-peptide complex
Cell Type
T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
TCRs
Antigen References

1. Kuchroo VK, et al. 2002. Annu. Rev. Immunol. 20:101.
2. Venturi V, et al. 2008. Nat. Rev. Immunol. 8:231.
3. Matsumoto Y, et al. 2003. J. Immunol. 170:4846.
4. Killestein J, et al. 2002. Ann. Neurol. 51:467.

Gene ID
6957 View all products for this Gene ID
UniProt
View information about TCR Vbeta5 on UniProt.org
Go To Top Version: 2    Revision Date: 12.14.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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