- Clone
- QA18A66 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- HTT, HD, IT15, LOMARS
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
948901 | 25 µg | 129 CHF | ||||
948902 | 100 µg | 323 CHF |
Huntingtin (HTT) is ubiquitously expressed throughout the nervous tissue and is required for normal development. HTT is associated with vesicles and microtubules and may play a role in axonal transport. Huntington disease (HD) is caused by mutated HTT, which results from an abnormally expanded polyglutamine (polyQ) stretch derived from CAG repeats in its N-terminal. Aggregation of mutated HTT causes cellular toxicity and leads to cell death, therefore, reducing HTT aggregates may be a strategy to slow down disease progression.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Partial recombinant human Huntingtin protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration of 5.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Signals were detected on FFPE human brain tissues using this antibody.
- RRID
-
AB_2904463 (BioLegend Cat. No. 948901)
AB_2904463 (BioLegend Cat. No. 948902)
Antigen Details
- Structure
- Huntingtin is a 3,144 amino acid protein with a molecular mass of 348 kD.
- Distribution
-
Brain and peripheral nerves/Neuronal cells
- Function
- HTT protein maintains tissue homeostasis by regulating vesicular transport and recycling, cell division, ciliogenesis, endocytosis, autophagy, and gene transcription.
- Interaction
- HTT protein interacts with dynein/dynactin for vesicle transport and cell division, Hip1 for endocytosis, GTPase Rab11 for vesicle recycling, p62 for autophagy induction, and CBP, NeuroD, SP1, NF-κB, p53 for transcriptional regulations.
- Cell Type
- Neurons
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience
- Molecular Family
- Microtubules, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Leavitt BR, et al. 2020. JAMA Neurol. 77:764-772.
- McColgan P, et al. 2019. Eur J Neurol. 25:24-34.
- Saudou F, et al. 2016. Neuron. 89:910-26.
- Gene ID
- 3064 View all products for this Gene ID
- UniProt
- View information about Huntingtin on UniProt.org
Other Formats
View All Huntingtin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Huntingtin Recombinant Antibody | QA18A66 | IHC-P |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Huntingtin Recombinant Antibody
IHC staining of anti-Huntingtin recombinant antibody (clone ...
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