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Purified anti-MMP1 Antibody

Pricing & Availability
Clone
F15P3B6 (See other available formats)
Regulatory Status
RUO
Other Names
CLG, CLGN, Fibroblast collagenase, Interstitial collagenase, MMP-1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
F15P3B6_012011
Recombinant MMP1 was resolved by electrophoresis, transferred to nitrocellulose, and probed with purified anti-MMP1 antibody (clone F15P3B6). Proteins were visualized using a goat anti-mouse IgG secondary conjugated to HRP and chemiluminescence detection.
  • F15P3B6_012011
    Recombinant MMP1 was resolved by electrophoresis, transferred to nitrocellulose, and probed with purified anti-MMP1 antibody (clone F15P3B6). Proteins were visualized using a goat anti-mouse IgG secondary conjugated to HRP and chemiluminescence detection.
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634702 100 µg 229 CHF
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Description

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade substances within the extracellular matrix. The MMP family includes six different groups of enzymes: collagenases, gelatinases, stromelysins, transmembrane MMPs, matrilysins and others. MMPs are secreted as proenzymes that have to be cleaved in order to be activated. Other MMPs, plasmins as well as other factors activate MMPs. MMPs are thought to play an important role in tissue remodeling associated with various physiological and pathological processes. MMP1 cleaves collagens of types I, II, III, VII and X.MMP1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction. Clone F15P3B6 has been shown to be useful for western blotting and immunohistochemistry of human MMP1.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Ovalbumin-conjugated synthetic peptide CSSFGFPRTVKH
Formulation
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
IHC-P - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 4 µg/ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Murray G et al. 1998. Gut. 43:791.
  2. Murray G et al. 1998. J. Pathol. 185:256.
Product Citations
  1. Van Den Eeckhout B, et al. 2023. Int J Mol Sci. :24. PubMed
RRID
AB_2144281 (BioLegend Cat. No. 634702)

Antigen Details

Structure
Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains, predicted molecular weight approximately 54 kD.
Distribution

Extracellular

Function
MMP1 cleaves collagens of types I, II, III, VII and X. MMP-1 is thought to play an important role in rheumatoid and osteo-arthritis pathogenesis as mediators of cartilage and bone destruction.
Interaction
MCP1, MCP3, MCP4, TIMP-1, MMP7, Collagen type II α1, IBP-3, Integrin α2, CD44, CD147, Brevican, Chymase 1, Aggrecan 1
Biology Area
Angiogenesis, Cell Adhesion, Cell Biology, Neuroinflammation, Neuroscience
Molecular Family
Enzymes and Regulators
Antigen References

1. Boire A, et al. 2005. Cell 120:303

Gene ID
4312 View all products for this Gene ID
UniProt
View information about MMP-1 on UniProt.org
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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