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Purified anti-mouse CD183 (CXCR3) Antibody

Pricing & Availability
Clone
S18001A (See other available formats)
Regulatory Status
RUO
Other Names
CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R)
Isotype
Rat IgG2b, κ
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Product Citations
publications
S18001A_PURE_CD183_Antibody_071618
C57BL/6 splenocytes stained with CD45R/B220 FITC and purified CD183 (CXCR3, clone S18001A) (left) or purified Rat IgG2b κ (right), followed by anti-Rat IgG PE.
  • S18001A_PURE_CD183_Antibody_071618
    C57BL/6 splenocytes stained with CD45R/B220 FITC and purified CD183 (CXCR3, clone S18001A) (left) or purified Rat IgG2b κ (right), followed by anti-Rat IgG PE.
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155902 500 µg 411 CHF
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Description

CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CXCR3-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2750166 (BioLegend Cat. No. 155902)

Antigen Details

Structure
38 kD seven pass transmembrane receptor coupled to G-protein.
Distribution

T cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors

Function
Essential in T cell recruitment to sites of inflammation
Ligand/Receptor
CXCL10, CXCL9, CXCL11 and CXCL4
Cell Type
Dendritic cells, Hematopoietic stem and progenitors, T cells
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References
  1. Farber JM. 1997. J. Leukoc. Biol. 61(3):\246-57.
  2. Bonecchi R, et al. 1998. J. Exp. Med. 187(1):129-34.
  3. Aota K, et al. 2018. J. Oral. Pathol. Med. 12756.
  4. Kim B, et al. 2018. Data. Brief. 18:518-522.
  5. Saahene RO, et al. 2018. Cancer Biother. Radiopharm. 2450.
Gene ID
12766 View all products for this Gene ID
UniProt
View information about CD183 on UniProt.org
Go To Top Version: 1    Revision Date: 07.17.2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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