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- Clone
- S17004A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Chemoattractant receptor-homologous molecule expressed on Th2 cells, GPR44, G-protein coupled receptor 44, DP2
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Mouse CD294 transfectant Ba/F3 cells were stained with purified anti-mouse CD294 (CRTH2) (clone S17004A) (filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by Alexa Fluor® 647 rat anti-mouse IgG2a.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 165102 | 100 µg | 118 CHF | ||||
CD294, also known as CRTH2, is a seven-transmembrane protein coupled with heterotrimeric G proteins. CRTH2 is the prostaglandin D2 receptor and is expressed by Th2 cells, eosinophils, and basophils. CD294 prevents the apoptosis of Th2 cells and mediates the chemotaxis of CRTH2 expressing cells to the sites of allergic inflammation, such as the asthmatic lung.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Mouse CD294 transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC – Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2924496 (BioLegend Cat. No. 165102)
Antigen Details
- Structure
- Seven-transmembrane protein coupled with G proteins
- Distribution
-
Th2 cells, eosinophils, basophils
- Function
- Chemotaxis of eosinophils, basophils and Th2 cells, prevention of apoptosis in Th2 cells
- Interaction
- Heterotrimeric G proteins
- Ligand/Receptor
- Prostaglandin D2
- Cell Type
- Basophils, Eosinophils, Th2
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
- Abe H, et al. 1999. Gene. 227:71-7.
- Hata AN, et al. 2003. J Pharmacol Exp Ther. 306:463
- Luster AD and Tager AM. 2004. Nat Rev Immunol. 4:711-24
- Gene ID
- 14764 View all products for this Gene ID
- UniProt
- View information about CD294 on UniProt.org
Related FAQs
Other Formats
View All CD294 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD294 (CRTH2) | S17004A | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD294 (CRTH2)
Mouse CD294 transfectant Ba/F3 cells were stained with purif...
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