Purified anti-mouse CD317 BST2, PDCA-1 Antibody anti-CD317

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Clone: 129C1 (See other available formats)
Regulatory Status: RUO
Other Names: BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, PDCA-1
Isotype: Rat IgG2b, κ
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Product Citations: publications

A_129C1_PE_092409 — SJL mouse splenocytes double stained with 129C1 PE and CD11c (N418) APC

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127102

100 µg

147 CHF

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Description

CD317, known as BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, or PDCA-1, is type II transmembrane glycoprotein with a molecular mass of 29-33 kD. It is predominantly expressed on Type I IFN-producing cells (IPCs) in naïve mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. It is highly expressed on terminally differentiated normal plasmacytoid dendritic cells and some tumor cells, such as multiple myeloma, renal cell carcinoma, and melanoma cells. BST2 is a recently identified as IFN-induced cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. BST2 has been found to be the natural ligand of ILT7 in human model.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse plasmacytoid dendritic cells (DCs)
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10⁶ cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_1953279 (BioLegend Cat. No. 127102)

Antigen Details

Structure: Type II transmembrane glycoprotein with a molecular mass of 29-33 kD.
Distribution: Expressed on type I IFN-producing cells, plasmacytoid dendritic cells, and neoplastic B cells, such as multiple myeloma.
Function: Recently identified as antiviral protein that blocks the release of nascent retrovirus or other particles from infected cells.
Cell Type: Dendritic cells, B cells
Biology Area: Immunology, Innate Immunity, Costimulatory Molecules
Molecular Family: CD Molecules
Antigen References: 1. Douglas JL. et al. 2009. J Virol. 83(16):7931
2. Cao W et al. 2009. J. Exp. Med. 206(7):1603
3. Neil SJ. et al. 2008. Nature 451:425
Gene ID: 69550 View all products for this Gene ID
UniProt: View information about CD317 on UniProt.org

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Other Formats

View All CD317 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse CD317 (BST2, PDCA-1)	129C1	FC,IP
PE anti-mouse CD317 (BST2, PDCA-1)	129C1	FC
Pacific Blue™ anti-mouse CD317 (BST2, PDCA-1)	129C1	FC
Alexa Fluor® 647 anti-mouse CD317 (BST2, PDCA-1)	129C1	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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