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- Clone
- S20017B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Interleukin-21
- Isotype
- Rat IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
PMA+ ionomycin-stimulated (4 hours, in presence of brefeldin A) Th17-polarized C57BL/6 mouse CD4 T cells were stained with anti-mouse CD3ɛ APC. After fixation and permeabilization, cells were stained intracellularly with purified anti-mouse IL-21 (clone S20017B) (left) or purified rat IgG1, κ isotype control (right), followed by anti-rat IgG1 PE.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 122202 | 100 µg | 347 CHF | ||||
Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT cells and CD4+ T cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2941414 (BioLegend Cat. No. 122202)
Antigen Details
- Structure
- Interleukin
- Distribution
-
CD4 activated T cells, Th17 cells, Th2 cells
- Function
- Immunomodulation
- Ligand/Receptor
- IL-21R
- Cell Type
- NKT cells, T cells, Tfh, Th17, Th2
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
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- Parrish-Novak J, et al. 2000. Nature. 408:57-63.
- Mehta DS, et el. 2004. Immunol Rev. 202:84-95.
- Gene ID
- 60505 View all products for this Gene ID
- UniProt
- View information about IL-21 on UniProt.org
Other Formats
View All IL-21 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse IL-21 | S20017B | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse IL-21
PMA+ ionomycin-stimulated (4 hours, in presence of brefeldin...
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