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Purified anti-mouse Ly49G Antibody

Pricing & Availability
Clone
AT8 (See other available formats)
Regulatory Status
RUO
Other Names
Ly-49G, Ly49g, Killer cell lectin-like receptor 7, Klra7
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
AT8_PE_1_012612
Balb/c mouse splenocytes stained with CD49b (DX5) APC and AT8 PE (top) or mouse IgG2a, κ PE isotype control (bottom).
  • AT8_PE_1_012612
    Balb/c mouse splenocytes stained with CD49b (DX5) APC and AT8 PE (top) or mouse IgG2a, κ PE isotype control (bottom).
  • AT8_PE_2_012612
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137402 500 µg 253 CHF
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Description

Ly49G is a type II transmembrane protein belonging to the family of Ly49 proteins, each having specificity for a small repertoire of MHC I alleles that are generally recognized in a peptide-independent manner.   The Ly49 family of MHC class I receptors shows a high degree of variability between mouse strains.  It is expressed on a subset of NK cells and some NKT cell lines.  The AT8 antibody reacts with the Ly49G receptor from BALB/c, 129/J, 129Sv/J, SJL, FVB/N, A/J, C3H/HeJ, C3H/HeNCr, CBA/J, and CBA/NCr mice.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
IL-2-activated 129/J NK cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Makrigiannis AP, et al. 2004.  J. Immunol.  172:1414.
RRID
AB_10551620 (BioLegend Cat. No. 137402)

Antigen Details

Structure
A type II transmembrane protein belonging to Ly49 family.
Distribution

Subset of NK cells and some NKT cell lines

Function
Allele-specific MHC recognition
Ligand/Receptor
MHC class I molecules
Cell Type
NK cells, NKT cells
Biology Area
Immunology, Innate Immunity
Molecular Family
MHC Antigens
Antigen References
  1. Lavender KJ, et al. 2006. J. Immunol. 177:8578.
  2. Pascal V, et al. 2007. J. Immunol.. 179:1751.
  3. Lavender KJ, et al. 2007. J. Immunol. 179:6856.
  4. Rouhi A, et al. 2007. Mol. Immunol. 44(5):821.
Gene ID
16638 View all products for this Gene ID
UniProt
View information about Ly49G on UniProt.org
Go To Top Version: 1    Revision Date: 11.30.2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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