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Purified anti-mouse lymphotoxin beta receptor (LTβR) Antibody

Pricing & Availability
Clone
5G11 (See other available formats)
Regulatory Status
RUO
Other Names
LTbR, TNFRIII, TNF receptor-related protein (TNFRrp)
Isotype
Rat IgG2a, κ
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Product Citations
publications
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134402 100 µg 235 CHF
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Description

LTβR is a type I transmembrane glycoprotein and member of the TNF receptor superfamily. It is a 61 KDa receptor for the mouse LTα1β2 and LIGHT. Northern blot analysis of tissues from adult mice showed that expression levels of LTβR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. It was reported that LTβR is expressed on stromal cells, monocytes, and certain embryonic epithelial layers. LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
E.coli expressed extracellular domain of mouse lymphotoxin beta receptor
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
 
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
RRID
AB_1659177 (BioLegend Cat. No. 134402)

Antigen Details

Distribution

Expressed on stromal cells, monocytes, and certain embryonic epithelial layers.

Function
LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.
Ligand/Receptor
LTα1β2 and LIGHT
Cell Type
Embryonic Stem Cells, Epithelial cells, Monocytes
Biology Area
Immunology, Stem Cells
Molecular Family
Adhesion Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Force WR, et al. 1995. J. Immunol. 155:5280
2. Tamada K, et al. 2000. J. Immunol. 164:4105
3. Browing JL, et al. 1997. J. Immunol. 159:3288
4. Futterer A, et al. 1998. Immunity 9:59
5. Nakamura T, et al. 1995. Genomics 30:312
6. Crowe P, et al. 1996. Science 264:707
7. Dejardin E, et al. Immunity 2002. 17(4):525

Gene ID
17000 View all products for this Gene ID
UniProt
View information about LT-betaR on UniProt.org
Go To Top Version: 2    Revision Date: 06.04.2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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