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Purified anti-mouse TCR γ/δ Recombinant Antibody

Pricing & Availability
Clone
QA20A16 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor gamma/delta
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA20A16_PURE_TCRgammaslashdelta_RECOM_Antibody_101421
C57BL/6 mouse splenocytes were stained with anti-mouse CD3 APC and anti-mouse TCR γ/δ recombinant (clone QA20A16) purified (left) or mouse IgG1, κ isotype control (right) followed by anti-mouse IgG1 PE.
  • QA20A16_PURE_TCRgammaslashdelta_RECOM_Antibody_101421
    C57BL/6 mouse splenocytes were stained with anti-mouse CD3 APC and anti-mouse TCR γ/δ recombinant (clone QA20A16) purified (left) or mouse IgG1, κ isotype control (right) followed by anti-mouse IgG1 PE.
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107302 100 µg 106 CHF
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Description

T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). TCR γ/δ belongs to the immunoglobulin superfamily, which is involved in the recognition of certain bacterial and tumor antigens bound to MHC class I. The γ/δ TCR associates with CD3 and is expressed on a T cell subset found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8- although some are CD8+. T cells expressing the γ/δ TCR have been shown to play a role in oral tolerance, tumor-associated tolerance, and autoimmune disease. It has been reported that γ/δ T cells also play a principal role in antigen presentation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Clone QA20A16 is able to completely block the staining of clone GL3 on target cells.

RRID
AB_2904279 (BioLegend Cat. No. 107302)

Antigen Details

Structure
Ig superfamily, associates with CD3 complex
Distribution

T cell subset in thymus, intestinal epithelium, peripheral lymphoid tissues and peritoneum, most γ/δ T cells are CD4-/CD8-, some are CD8+.

Function
Antigen recognition
Interaction
CD3 complex
Ligand/Receptor
Some bacterial or tumor antigens bound to MHC class I.
Cell Type
Lymphocytes, T cells
Biology Area
Adaptive Immunity, Cell Biology, Immunology, Innate Immunity
Molecular Family
TCRs
Antigen References
  1. Skarstein K, et al. 1995. Immunology. 81:497.
  2. Harrison LC, et al. 1996. J Exp Med. 184:2167.
  3. Wildner G, et al. 1996. Eur J Immunol. 26:2140.
  4. Brandes M, et al. 2005. Science. 309:264.
Gene ID
110066 View all products for this Gene ID 110067 View all products for this Gene ID
UniProt
View information about TCR gamma/delta on UniProt.org
Go To Top Version: 1    Revision Date: 10.14.2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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