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Purified anti-NR4A2 (Nurr1) Antibody

Pricing & Availability
Clone
10A4B48 (See other available formats)
Regulatory Status
RUO
Other Names
Nuclear receptor subfamily 4 group A member 2, NUR-related factor 1 (Nurr1), Orphan nuclear receptor NURR1
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
10A4B48_PURE_NR4A2_Antibody_WB_120115
Total cell lysate from mouse brain (lane 1) and human U251 cells (lane 2) were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-mouse NR4A2 (clone 10A4B48) antibody. Proteins were visualized using an HRP-conjugated goat anti-rat-IgG secondary and chemiluminescence detection.
  • 10A4B48_PURE_NR4A2_Antibody_WB_120115
    Total cell lysate from mouse brain (lane 1) and human U251 cells (lane 2) were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified monoclonal anti-mouse NR4A2 (clone 10A4B48) antibody. Proteins were visualized using an HRP-conjugated goat anti-rat-IgG secondary and chemiluminescence detection.
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682002 100 µg 335 CHF
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Description

NR4A2, also known as Nurr1, is a member of the orphan nuclear receptor family 4 subgroup A (NR4A) superfamily. NR4A2 is a transcription factor that regulates expression of the key enzyme required for the synthesis of dopamine and is essential in the differentiation, maturation, and survival of dopaminergic neurons. NR4A2 is involved in the regulation of several neuronal events, including axon outgrowth, neuronal patterning, and terminal differentiation. Mutation or dysregulation of NR4A2 have been linked to brain diseases such as Alzheimer's disease, Schizophrenia, and Parkinson's disease. NR4A2 is pivotal for the function of regulatory T cells and has been found to play regulatory roles in inflammatory arthritis. NR4A2 is expressed at elevated levels in inflamed joint tissues from patients with rheumatoid arthritis, osteoarthritis, and psoriatic arthritis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Partial mouse NR4A2 recombinant protein (1-200 a.a.) expressed in E. coli.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2566567 (BioLegend Cat. No. 682002)

Antigen Details

Structure
598 amino acids with a predicted molecular weight of 66.6 kD. Contains two zinc finger domains that are responsible for DNA binding.
Distribution
Nucleus and cytoplasm.
Function
NR4A2 is a transcription factor, playing important roles in dopaminergic neuron signaling, brain development, and inflammatory responses during arthritis.
Interaction
Interacts with PER2, NCOR2, SFPQ, NCOR2, SIN3A, and HADC1.
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Transcription Factors
Molecular Family
Nuclear Markers
Antigen References

1. Liu H, et al. 2015. Neurosci. Lett. 598:85.
2. Navone ND, et al. 2014. J. Neuroimmunol. 272:99.
3. Chen S, et al. 2013. J. Mol. Neurosci. 51:719.
4. Han Y, et al. 2013. Cancer 119:3436.
5. Sekiya T, et al. 2011. Nat. Commun. 2:269.
6. Aherne CM, et al. 2009. Mol. Immunol. 46:3345.

Gene ID
18227 View all products for this Gene ID
UniProt
View information about NR4A2 on UniProt.org
Go To Top Version: 1    Revision Date: 12.02.2015

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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