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Purified anti-p120 Catenin Antibody (Previously Covance catalog# MMS-5040)

Pricing & Availability
Clone
2B12 (See other available formats)
Regulatory Status
RUO
Other Names
CAS, p120, CTNND, P120CAS, P120CTN, p120(CAS), p120(CTN), catenin delta-1
Previously
Covance Catalog# MMS-5040
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
2B12_Putified_p120_Catenin_Antibody_031519.png
Western blot of purified anti-p120 Catenin antibody (clone 2B12) (lanes 1 & 2) and isotype-matched IgG1 control (lanes 3 & 4). Lane 1, 3: Molecular weight marker; Lane 2, 4: 20 µg of mouse lung lysate. The blots were incubated with 5 µg/mL of the clone 2B12 or mouse IgG1 overnight at 4°C, followed by incubation with HRP labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • 2B12_Putified_p120_Catenin_Antibody_031519.png
    Western blot of purified anti-p120 Catenin antibody (clone 2B12) (lanes 1 & 2) and isotype-matched IgG1 control (lanes 3 & 4). Lane 1, 3: Molecular weight marker; Lane 2, 4: 20 µg of mouse lung lysate. The blots were incubated with 5 µg/mL of the clone 2B12 or mouse IgG1 overnight at 4°C, followed by incubation with HRP labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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828301 100 µL 275 CHF
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Description

p120/Catenin delta-1 (CTNND1) is a membrane protein that binds to cadherins and participates in signal transduction.  It is the prototypic member of a growing subfamily of Armadillo-domain proteins found at cell-cell junctions and in nuclei.  Known to bind specifically to presenilin 1, it regulates the maintenance of dendrites and dendritic spines in mature cortex.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
This monoclonal antibody was raised against tyrosine phosphoproteins purified from chicken embryonic fibroblasts (CEFs) expressing pp60/c-src 527F and 2A/527F.
Formulation
Phosphate-buffered solution.
Preparation
The antibody was purified by affinity chromatography.
Concentration
1 mg/ml
Storage & Handling
This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
Application

WB - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 5 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Kanner S., et al. Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Mol Cell Bio, 11(2): 713-720, February 1991.
  2. Kanner S., et al. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proc Natl Acad Sci U.S.A., 87(9): 3328-3332, May 1990.
  3. Staddon JM, et al. 1995. J. Cell. Biol. 130:369. (WB, IP)
  4. Kim L and Wong TW, et al. 1995. Mol. Cell. Biol. 15:4553. (WB, IP)
Product Citations
  1. Alharatani R, et al. 2020. Hum Mol Genet. 29:1900. PubMed
RRID
AB_2564919 (BioLegend Cat. No. 828301)

Antigen Details

Structure
Expected MW: 115 kD
Biology Area
Cell Biology, Neuroscience, Synaptic Biology
Molecular Family
Adhesion Molecules
Gene ID
1500 View all products for this Gene ID
UniProt
View information about p120 Catenin on UniProt.org
Go To Top Version: 4    Revision Date: 07.09.2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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