- Clone
- SS1A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
635201 | 25 µg | 112 CHF |
RIG-1/DDX58(Retinoic acid-inducible gene 1 protein/ DEAD-box protein 58) is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 and MDA5 (melanoma differentiation-associated gene 5) are key intracellular receptors that sense intracellular viral infection and trigger a signal forinnate antiviral responses including the production of typeI IFN. Clone SS1A has been shown to be useful for western blotting of the mouse RIG-1 protein.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Peptide-KLH, C-terminal end of murine RIG-1
- Formulation
- This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- Upon receipt, store undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Product Citations
-
- RRID
-
AB_940599 (BioLegend Cat. No. 635201)
Antigen Details
- Structure
- RIG-1 is an RNA helicase that belongs to the DEAD/H box. Contains 2 CARD domains, a helicase ATP-binding domain and a helicase C-terminal domain. Predicted molecular weight approximately 107 kD.
- Distribution
-
Cytoplasm.
- Function
- Involved in innate immune defense against viruses. RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. RIG-1 is one of the key intracellular receptors that sense intracellular viral infection and trigger a signal for
- Interaction
- Cardif
- Biology Area
- Cell Biology, Transcription Factors
- Antigen References
-
1. Imaizumi T, et al. 2002. Biochem. Biophys. Res. Commun. 292:274
2. Kato H, et al. 2006. Nature 441:101
3. Kato H, et al. 2005. Immunity 23:19 - Gene ID
- 109906 View all products for this Gene ID
- UniProt
- View information about RIG-1 on UniProt.org
Related FAQs
Other Formats
View All RIG-1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-RIG-1 | SS1A | WB |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-RIG-1
Western blot analysis of extracts from Raw 264.7 cells starv...
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