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Purified anti-SLC6A1 Antibody

Pricing & Availability
Clone
A18095C (See other available formats)
Regulatory Status
RUO
Other Names
GAT-1, GABA Transporter
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
A18095C_PURE_SLC6A1_Antibody_062419
Western blot of purified anti-SLC6A1 antibody (clone A18095C). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 2 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • A18095C_PURE_SLC6A1_Antibody_062419
    Western blot of purified anti-SLC6A1 antibody (clone A18095C). Lane 1: Molecular weight marker; Lane 2: 20 µg of human brain lysate; Lane 3: 20 µg of mouse brain lysate; Lane 4: 20 µg of rat brain lysate. The blot was incubated with 2 µg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP-labeled goat anti-mouse IgG (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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867401 25 µg 106 CHF
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867402 100 µg 276 CHF
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Description

SLC6A1 is the gene that encodes GABA transporter 1 (GAT1) and functions as the major presynaptic protein in neurons involved in the removal of excessive GABA from the synaptic cleft and the extrasynaptic space. Diseases associated with GAT1 include neurodevelopmental disorders such as schizophrenia and seizure.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
KLH-conjugated C-terminal peptide of mouse SLC6A1.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Avoid boiling lysates before loading to SDS for WB.

RRID
AB_2810801 (BioLegend Cat. No. 867401)
AB_2810801 (BioLegend Cat. No. 867402)

Antigen Details

Structure
GAT1 is a 599 amino acid protein with predicted and observed molecular mass of ~ 67 kD.
Distribution

Tissue Distribution: Brain
Cellular Distribution: Plasma membrane

Function
GAT1 is a GABA transporter protein that removes excessive GABA from the synaptic cleft and the extrasynaptic space.
Interaction
MPP5, STX1A
Ligand/Receptor
GABA
Cell Type
Astrocytes, GABAergic Neurons, Mature Neurons, Neurons, Oligodendrocytes
Biology Area
Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers, Synaptic Biology
Molecular Family
Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
Antigen References
  1. Zafar S, et al. 2018. Front Chem. 6:397.
  2. Lie MEK, et al. 2017. Adv. Neurobiol. 16:137-167.
  3. Zhou Y, Danbolt NC. 2013. Front Endocrinol (Lausanne). 4:165.
Gene ID
6529 View all products for this Gene ID 232333 View all products for this Gene ID 79212 View all products for this Gene ID
UniProt
View information about SLC6A1 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 06.24.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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