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Purified anti-UBE2V1 Antibody

Pricing & Availability
Clone
A18196A (See other available formats)
Regulatory Status
RUO
Other Names
Ubiquitin-conjugating enzyme E2 variant 1, UEV-1, CROC-1, TRAF6-regulated IKK activator 1 beta Uev1A
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
A18196A_PURE_UBE2V1_Antibody_1_012820
Western blot of purified anti-UBE2V1 antibody (clone A18196A). Lane 1: Molecular weight marker; Lane 2: 20 μg of human brain lysate; Lane 3: 20 μg of mouse brain lysate; Lane 4: 20 μg of rat brain lysate. The blot was incubated with 5 μg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • A18196A_PURE_UBE2V1_Antibody_1_012820
    Western blot of purified anti-UBE2V1 antibody (clone A18196A). Lane 1: Molecular weight marker; Lane 2: 20 μg of human brain lysate; Lane 3: 20 μg of mouse brain lysate; Lane 4: 20 μg of rat brain lysate. The blot was incubated with 5 μg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
  • A18196A_PURE_UBE2V1_Antibody_2_012820
    Western blot of purified anti-UBE2V1 antibody (clone A18196A). Lane 1: Molecular weight marker; Lane 2: 20 μg of Drosophila head lysate; Lane 3: 20 μg of Drosophila S2 cell (embryonic) lysate. The blot was incubated with 5 μg/mL of the primary antibody overnight at 4°C, followed by incubation with HRP goat anti-mouse IgG antibody (Cat. No. 405306). Enhanced chemiluminescence was used as the detection system.
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870701 25 µg 106 CHF
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870702 100 µg 276 CHF
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Description

Ubiquitination is a common post-translational modification of proteins and plays an important role in protein homeostasis. UBE2V1 encodes one of the ubiquitin-conjugating E2 enzyme variant proteins (UBE2V), which lacks the conserved cysteine residue required for the catalytic activity of E2s. Elevated expression of UBE2V1 has been associated with tumor development; however, it is not clear whether it functions as an oncogene or tumor suppressor gene. In addition, UBE2V1 is a key component in TRAF6 to control NF-κB activation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat, Drosophila
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant human UBE2V1 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

WB - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 1.0 - 10 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2832874 (BioLegend Cat. No. 870701)
AB_2832874 (BioLegend Cat. No. 870702)

Antigen Details

Structure
Human UBE2V1 is a 147 amino acid protein with a predicted molecular mass of 16 kD.
Distribution

Tissue distribution: Ubiquitously expressed

Cellular distribution: Cytosol, nucleus

Function
UBE2V1 is a ubiquitin-conjugating enzyme.
Cell Type
Astrocytes, Neurons
Biology Area
Cell Biology, Cell Cycle/DNA Replication, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Ubiquitin/Protein Degradation
Molecular Family
Enzymes and Regulators, Ligases
Antigen References
  1. Ma L, et al. 1998. Oncogene. 17:1321-6. 
  2. Shen T, et al. 2018. J. Hematol. Oncol. 11:95. 
  3. Wu X, Karin M. 2015. Immunol. Rev. 266:161-74. 
Gene ID
7335 View all products for this Gene ID
UniProt
View information about UBE2V1 on UniProt.org
Go To Top Version: 1    Revision Date: 01.28.2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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