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Recombinant Human PTX3 (ELISA Std.)

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Regulatory Status
RUO
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RECOM_HU_PTX3_080119.png
Figure was created using pure MNB5 (Cat. NO 537902) antibody as the capture in a sandwich ELISA assay in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109)
  • RECOM_HU_PTX3_080119.png
    Figure was created using pure MNB5 (Cat. NO 537902) antibody as the capture in a sandwich ELISA assay in conjunction with the biotinylated MNB4 antibody (Cat. No. 538004) as the detection antibody and recombinant Human PTX3 (ELISA Std.) (Cat. No. 786109)
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786109 4 pack 94 CHF
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Description

PTX3 is part of the pentraxin family which is characterized by a cyclic multimeric structure. Penatraxins are acute phase proteins that act as pattern recognition receptors. PTX3 is a long pentraxin containing a C terminal domain similar to other members of the pentraxin family and a unique N terminal domain. Inflammatory signals stimulate PTX3 production by a variety of cells including mononuclear phagocytes, dendritic cells, fibroblasts, and endothelial cells.

Serum levels of PTX3 increase rapidly in response to a variety of inflammatory and infectious conditions including endotoxic shock and sepsis. PTX3 has been proposed as an early diagnostic marker for septic shock. PTX3 can activate the classical complement pathway, aiding in pathogen recognition by macrophages and dendritic cells. PTX3 is also believed to play an important role in protection against autoimmunity by enhancing complement-mediated clearing of apoptotic cells and restricting cross presentation. Current research has also indicated that PTX3 is involved in initiating the process of tissue repair and plays a role in female fertility. PTX3 is believed to be involved in cancer-related inflammation and high PTX3 levels have been correlated with clinical stage and severity for various cancers

Product Details
Technical Data Sheet (pdf)

Product Details

Source
A DNA sequence encoding the human PTX3 (NP_002843.2) (Met 1-Ser 381) was fused with a polyhistidine tag at the C-terminus.
Purity
>97% as determined by SDS-PAGE
Formulation
Lyophillized in sterile-filtered PBS, pH 7.2, containing 1% BSA, 0.09% sodium azide and protease inhibitors
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
Unopened vials can be stored between 2°C and 8°C until the expiration date. Prior to use, reconstitute the lyophilized powder with 0.2 mL of PBS containing a carrier protein (e.g., 1% BSA, protease free), pH7.4. Re-cap vial, vortex. Allow the reconstituted standard to sit at room temperature for 15 minutes, vortex again to mix completely. The reconstituted standard stock solution can be aliquoted into polypropylene vials and stored at -70°C for up to one month. Do not re-use diluted standards. Avoid repeated freeze/thaw cycles.
Activity
Testing in progress
Application

ELISA - Quality tested
Recommended Usage

Each lot of this protein is quality control tested by ELISA assay. For use as an ELISA standard, a standard curve comprised of doubling dilutions from 6000  to 93.75 pg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This Human PTX3 protein is useful as a standard for a human PTX3 sandwich ELISA, using unlabeled MNB5 antibody (catalog #537902) as capture and bionylated MNB4 antibody (catalog #538004) as detection.

Antigen Details

Distribution

Dendritic cells, Endothelial cells, Fibroblasts, Monocytes

Function
Plays roles in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components, and female fertility.
Cell Type
Dendritic cells, Endothelial cells, Fibroblasts, Monocytes
Biology Area
Apoptosis/Tumor Suppressors/Cell Death, Innate Immunity
Gene ID
5806 View all products for this Gene ID
UniProt
View information about PTX3 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 08.01.2019

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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