- Clone
- S15040A (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CKR1, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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943704 | 1 mg | 1045 CHF | ||||
943703 | 100 µg | 325 CHF |
Select size of product is eligible for a 40% discount! Promotion valid until December 31, 2024. Exclusions apply. To view full promotion terms and conditions or to contact your local BioLegend representative to receive a quote, visit our webpage.
CD191, also known as CCR1, is a 41 kD, G-protein coupled receptor expressed predominantly by monocytes. CCR1 is also expressed by a subset of T cells and eosinophils. CCR1 positive cells can migrate in response to a CCL3 and CCL5 gradient. CCR1 knock-out studies suggest that this molecule plays an important role in inflammation and susceptibility to viruses and parasites.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant mouse CCR1 transfectants
- Formulation
- 0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative.
- Endotoxin Level
- Less than 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test.
- Preparation
- The Ultra-LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
- Concentration
- The antibody is bottled at the concentration indicated on the vial, typically between 2 mg/mL and 3 mg/mL. Older lots may have also been bottled at 1 mg/mL. To obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
- Application
-
Neut - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by neutralization of the chemotaxis induced by recombinant mouse CCL5 (RANTES) (Cat. No. 594206) on mouse Baf3-mCCR1 transfectant chemoattractant cells. ND50 range: 0.4 - 2 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2910504 (BioLegend Cat. No. 943704)
AB_2910504 (BioLegend Cat. No. 943703)
Antigen Details
- Structure
- CD molecules, cytokine/chemokine receptors, GPCR
- Distribution
-
Macrophages, monocytes, neutrophils, eosinophils, subset of T cells
- Function
- Chemotaxis, adhesion, regulating migration of cells in response to CCL3, CCL5, CCL7 and CCL23
- Interaction
- CCL15, Ga 14/16
- Ligand/Receptor
- CCL3, CCL5, CCL7 and CCL23
- Cell Type
- Eosinophils, Macrophages, Monocytes, Neutrophils
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1. Lionakis MS, et al. 2012. PLoS Pathog. 8:e1002865.
2. Gilliland CT, et al. 2013. J. Biol. Chem. 288:32194.
3. Gong X, et al. 1997. J. Biol. Chem. 272:11682.
4. Daugherty BL and Springer MS. 1997. Genomics. 41:294.
5. Pakianathan DR, et al. 1997. Biochemistry 36:9642. - Gene ID
- 12768 View all products for this Gene ID
- UniProt
- View information about CD191 on UniProt.org
Related FAQs
- Do you guarantee that your antibodies are totally pathogen free?
-
BioLegend does not test for pathogens in-house aside from the GoInVivo™ product line. However, upon request, this can be tested on a custom basis with an outside, independent laboratory.
- Does BioLegend test each Ultra-LEAF™ antibody by functional assay?
-
No, BioLegend does not test Ultra-LEAF™ antibodies by functional assays unless otherwise indicated. Due to the possible complexities and variations of uses of biofunctional antibodies in different assays and because of the large product portfolio, BioLegend does not currently perform functional assays as a routine QC for the antibodies. However, we do provide references in which the antibodies were used for functional assays and we do perform QC to verify the specificity and quality of the antibody based on our strict specification criteria.
- Does BioLegend test each Ultra-LEAF™ antibody for potential pathogens?
-
No, BioLegend does not test for pathogens in-house unless otherwise indicated. However, we can recommend an outside vendor to perform this testing as needed.
- Have you tested this Ultra-LEAF™ antibody for in vivo or in vitro applications?
-
We don't test our antibodies for in vivo or in vitro applications unless otherwise indicated. Depending on the product, the TDS may describe literature supporting usage of a particular product for bioassay. It may be best to further consult the literature to find clone specific information.
Other Formats
View All CD191 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Ultra-LEAF™ Purified anti-mouse CD191 (CCR1) Antibody | S15040A | Neut |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Ultra-LEAF™ Purified anti-mouse CD191 (CCR1) Antibody
Recombinant mouse CCL5 (RANTES) (Cat. No. 594206) (black cir...
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