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APC anti-human CD101 (BB27) Antibody

Pricing & Availability
Clone
BB27 (See other available formats)
Regulatory Status
RUO
Workshop
V T040
Other Names
V7, P126
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
BB27_APC_071108.jpg
Human peripheral blood lymphocytes stained with CD3 (UCHT1) FITC and BB27 APC
  • BB27_APC_071108.jpg
    Human peripheral blood lymphocytes stained with CD3 (UCHT1) FITC and BB27 APC
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331007 25 tests 161 CHF
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Description

CD101 is a type I transmembrane glycoprotein, known as V7, and P126. It is a 120 kD homodimer, the member of EWI family within Ig superfamily. CD101 is found on monocytes, granulocytes, dendritic cells, a subpopulation of peripheral blood T cells and activated T cells. It has been reported that CD101 expressing Tregs posses higher inhibitory function. The biological function of CD101 is still not clear. But it has been found that BB27 antibody is able to inhibit T cell proliferative responses and this inhibitory function can be overcome by high doses of IL-2. Activation of CD101 on dendritic cells is able to induce IL-10 production.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Gouttefangeas C, et al. 1994. Int. Immunol. 6:423
  2. Bouloc A, et al. 2000. Histopathology. 36:229
Product Citations
  1. Zhou J, et al. 2020. Oncol Lett. 1.336111111. PubMed
  2. Weisberg SP, et al. 2020. Cell Reports. 29(12):3916-3932.e5.. PubMed
  3. Richert-Spuhler LE, et al. 2021. Cell Reports Medicine. 2(6):100322. PubMed
  4. Evrard M et al. 2018. Immunity. 48(2):364-379 . PubMed
  5. Kwok I, et al. 2020. Immunity. 53(2):303-318.e5. PubMed
RRID
AB_2121761 (BioLegend Cat. No. 331007)

Antigen Details

Structure
Type I transmembrane glycoprotein, homodimer, Ig superfamily, 120 kD
Distribution

Monocytes, granulocytes, dendritic cells, T cell subset and activated T cells

Cell Type
Dendritic cells, Granulocytes, Monocytes, T cells
Biology Area
Immunology
Antigen References

1. Zola H, et al. Eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. A John Wiley & Sons Inc, Publication
2. Bagot M, et al. 1997. Tissue Antigen 50:439

Gene ID
9398 View all products for this Gene ID
UniProt
View information about CD101 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 3    Revision Date: 08.17.2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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