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PE anti-human CD36 Antibody

Pricing & Availability
Clone
5-271 (See other available formats)
Regulatory Status
RUO
Other Names
GPIIIb, GPIV
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
5-271_PE_CD36_Antibody_Updated_081117
Human peripheral blood platelets were stained with CD36 (clone 5-271) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
  • 5-271_PE_CD36_Antibody_Updated_081117
    Human peripheral blood platelets were stained with CD36 (clone 5-271) PE (filled histogram) or mouse IgG2a, κ PE isotype control (open histogram).
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336205 25 tests 122 CHF
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336206 100 tests 268 CHF
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Description

CD36 is an 85 kD integral membrane glycoprotein, also known as GPIIIb, or GPIV. It is expressed on various epithelial and endothelial cells as well as erythrocytes, platelets, macrophages/monocytes and some macrophage-derived dendritic cells. CD36 functions as a scavenger receptor, binding thrombospondin, long chain fatty acids, oxidized LDL, collagen type I, IV, and V as well as apoptotic cells. The 5-271 antibody has been reported to be useful for flow cytometry.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human platelets
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunofluorescence2.

Application References

(PubMed link indicates BioLegend citation)
  1. Stelner E, et al. 2006. J. Cell Sci. 119:459.
  2. Stewart DA, et al. 2012. Mol. Cancer Res. 10:727. (IF)
Product Citations
  1. Siepe DH, et al. 2022. Elife. 11:. PubMed
  2. Conforti A, et al. 2021. PLoS One. 16:e0259894. PubMed
  3. Philippeos C, et al. 2018. J Invest Dermatol. 138:811. PubMed
  4. Botha J, et al. 2021. Biomedicines. 9:. PubMed
  5. Lu YC, et al. 2018. Cell Rep. 25:2083. PubMed
  6. Oosenbrug T, et al. 2020. J Biol Chem. 295:14325. PubMed
  7. Nielsen M, et al. 2015. PLoS One. 10:121516. PubMed
  8. Kerdidani D, et al. 2022. J Exp Med. 219:. PubMed
RRID
AB_1575032 (BioLegend Cat. No. 336205)
AB_1575032 (BioLegend Cat. No. 336206)

Antigen Details

Structure
Integral membrane protein, CD36 family, single chain glycoprotein, 85-113 kD
Distribution

Expressed in various epithelial and endothelial cells, erythrocytes, platelets, monocytes/ macrophages, some macrophage-derived dendritic cells

Function
Scavenger receptor for thrombospondin, long chain fatty acids, anionic phospholipids, oxidized LDL, collagen types I, IV and V. Involved in recognition and phagocytosis of apoptotic cells, cell adhesion.
Ligand/Receptor
Thrombospondin, anionic phospholipids, oxidized LDL, collage types I, IV, and V
Cell Type
Dendritic cells, Endothelial cells, Epithelial cells, Erythrocytes, Macrophages, Monocytes, Platelets
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family
CD Molecules
Antigen References

1. Hogg N, et al. 1984. Immunology 53-753.
2. Greenwalt DE, et al. 1992. Blood 80:1105.
3. Armsesilla AL, et al.1994. J. Biol. Chem. 269:18985.
4. Endemann G, et al. 1993. J. Biol. Chem. 268:11811.

Gene ID
948 View all products for this Gene ID
UniProt
View information about CD36 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 3    Revision Date: 08.11.2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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