Purified anti-human CD48 Antibody anti-CD48

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Clone: BJ40 (See other available formats)
Regulatory Status: RUO
Other Names: Blast-1, SLAMF2, HuLy-m3
Isotype: Mouse IgG1, κ
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Product Citations: publications

Human peripheral blood lymphocytes stained with purified BJ40, followed by anti-mouse IgG FITC

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336702

100 µg

106 CHF

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Description

CD48 is a 40-47 kD GPI-anchored membrane protein, also known as Blast-1 and HuLy-m3. It is a member of the CD2 family that contains 2 IgSF domains and is widely expressed on both resting and activated hematopoietic cells with the exception of granulocytes, platelets, and erythrocytes. CD48 binds to CD2 at a considerably (>100-fold) lower affinity than CD58. It is thought to contribute to T cell activation. The cytoplasmic tail of CD48 has been shown to bind to the kinases Lck and Fyn.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Reported Reactivity: African Green, Baboon, Cynomolgus, Rhesus
Antibody Type: Monoclonal
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, it is recommended to use at ≤ 2.0 µg per 10⁶ cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation.
RRID: AB_1227561 (BioLegend Cat. No. 336702)

Antigen Details

Structure: CD2 family, contains 2 IgSF domains, GPI-membrane anchored, 40-47 kD
Distribution: Widely expressed on hematopoietic cells except granulocytes, platelets, and erythrocytes. Increased on T and B cells after activation
Function: Contributes to T cell antigen recognition
Ligand/Receptor: CD2
Cell Targets: Lck, Fyn interact with cytoplasmic domain
Cell Type: B cells
Biology Area: Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: Fisher RC and Thorley-Lawson DA. 1991. Mol. Cell. Biol. 11:1614.

Korinek V, et al. 1991. Immunogenetics 33:108.

Leukocyte Typing IV. Knapp W, et al. (Eds) Oxford University Press (1989)

Leukocyte Typing V. Schlossman S, et al. (Eds) Oxford University Press (1995)
Gene ID: 962 View all products for this Gene ID
UniProt: View information about CD48 on UniProt.org

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD48 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD48	BJ40	FC,IP
FITC anti-human CD48	BJ40	FC
PE anti-human CD48	BJ40	FC
TotalSeq™-A0029 anti-human CD48	BJ40	PG
TotalSeq™-C0029 anti-human CD48	BJ40	PG
PerCP/Cyanine5.5 anti-human CD48	BJ40	FC
APC anti-human CD48	BJ40	FC
PE/Cyanine7 anti-human CD48	BJ40	FC
TotalSeq™-B0029 anti-human CD48	BJ40	PG
TotalSeq™-D0029 anti-human CD48	BJ40	PG

Certificate of Analysis

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Go To Top Version: 2 Revision Date: 08.18.2022

For Research Use Only. Not for diagnostic or therapeutic use.

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