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APC anti-human CD317 (BST2, Tetherin) Antibody

Pricing & Availability
Clone
RS38E (See other available formats)
Regulatory Status
RUO
Workshop
VIII
Other Names
BST2, Tetherin, HM1.24, Bone marrow stromal antigen 2
Isotype
Mouse IgG1, κ
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Product Citations
publications
RS38E_APC_052710
Human peripheral blood monocytes stained with RS38E APC
  • RS38E_APC_052710
    Human peripheral blood monocytes stained with RS38E APC
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348410 100 tests 290€
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Description

CD317, also known as BST2, Tetherin, and HM1.24, is a type II transmembrane GPI-protein with a molecular weight of about 29-33 kD. It is an interferon-induced protein expressed on dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells, and some non-hematopoietic cells. BST2 inhibits cytokine production through interaction with ILT7 (CD85g). It is also involved in the regulation of B cell growth. More importantly, BST2 has been found to restrict the release of a number of viruses from infected cells, including all tested retroviruses (such as HIV-1) and some arenaviruses and filoviruses. In HIV-1 studies, it has been reported that BST2 retains the nascent virons on the surface of infected cells by incorporation of the protein into HIV-1 particles. HIV-1 Vpu is able to induce BST2 degradation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Cynomolgus, Rhesus
Reported Reactivity
African Green, Baboon, Pigtailed Macaque
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration, please enter the lot number in our Concentration and Expiration Lookup or Certificate of Analysis online tools.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Ishikawa J, et al. 1995. Genomics 26:527.
  2. Miyagi E, et al. 2011. J. Virol. 85:11981. PubMed
  3. Yokoyama T, et al. 2013. Int. J. Cancer. 132: 472. (FC) PubMed
Product Citations
  1. Alphonse N, et al. 2022. Cell. 185:2354. PubMed
  2. Taylor J, et al. 2015. J Virol. 89: 11820 - 11833. PubMed
  3. Rohani L, et al. 2020. Commun Biol. 0.466666667. PubMed
  4. Mahauad-Fernandez W, Okeoma C 2017. Cell Death Dis. 10.1038/cddis.2017.68. PubMed
  5. Eri Yamada et al. 2018. Cell host & microbe. 23(1):110-120 . PubMed
  6. OhAinle M et al. 2018. eLife. 7 pii: e39823. PubMed
  7. Heusinger E, et al. 2018. J Virol. 92:18. PubMed
  8. Presle A, et al. 2021. Current Biology. 31(10):2203-2213.e5. PubMed
  9. Sato K, et al. 2012. J Virol. 86:5000. PubMed
  10. Yoder A, et al. 2017. PLoS Pathog. 13(2):e1006226. PubMed
  11. Webb K et al. 2018. Frontiers in immunology. 2.574305556 . PubMed
  12. Simon Langer et al. 2019. eLife. 8 pii: e41930. PubMed
  13. Tokarev A, et al. 2013. J Virol. 87:2046. PubMed
  14. Hopfensperger K, et al. 2020. MBio. 11:00. PubMed
  15. Langer S, et al. 2015. PLoS One. 10: 0142118. PubMed
  16. Joas S, et al. 2018. Nat Commun. 9:902. PubMed
  17. Joas S, et al. 2020. Cell Rep. 30:2261. PubMed
RRID
AB_2067121 (BioLegend Cat. No. 348410)
Disclaimer

This product is manufactured and sold under a license and covered by a number of issued patents. Users who intend to file a patent relating to the use of this product or who intend to develop therapeutic use of this antibody are required to report to Biolegend in advance.

Antigen Details

Structure
Type II transmembrane, GPI-anchored protein, 29-33 kD
Distribution

Dendritic cells, plasma cells, B lymphoblast cells, monocytes, granulocytes, T cells, NK cells, stromal cells

Function
Regulate B cell growth, inhibit cytokine production, retain progeny virons on the surface of infected cells
Ligand/Receptor
ILT7 (CD85g)
Cell Type
B cells, Dendritic cells, Granulocytes, Monocytes, NK cells, Plasma cells, T cells
Biology Area
Costimulatory Molecules, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Sugamata OT, et al. 1999. Biochem. Bioph. Res. Co. 258:583.
2. Neil SJ, et al. 2008. Nature 451:425.
3. Fitzpatrick K, et al. 2010. PLoS Pathog. 6:e1000701.
4. Azuma KS, et al. 2008. Cancer Sci. 99:2461.
5. Cao W, et al. 2009. J. Exp. Med. 206:1603.
6. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers.

Gene ID
684 View all products for this Gene ID
UniProt
View information about CD317 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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