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APC anti-mouse CD202b (Tie-2, CD202) Antibody

Pricing & Availability
Clone
TEK4 (See other available formats)
Regulatory Status
RUO
Other Names
Tie-2, TEK
Isotype
Rat IgG1, κ
Ave. Rating
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Product Citations
publications
TEK4_APC_050411
Mouse endothelial cells bEnd.3 were stained with CD202b (clone TEK4) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
  • TEK4_APC_050411
    Mouse endothelial cells bEnd.3 were stained with CD202b (clone TEK4) APC (filled histogram) or rat IgG1, κ APC isotype control (open histogram).
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124009 25 µg 72€
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124010 100 µg 209€
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Description

CD202b, also known as Tie-2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in the quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 also binds to Ang-4.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
  2. Sanchez-Martin L, et al. 2011. Blood 117:88. PubMed
Product Citations
  1. Mo C, et al. 2022. EMBO J. 41:e108415. PubMed
  2. Julien A, et al. 2022. J Bone Miner Res. 37:1545. PubMed
  3. Tsioti I, et al. 2023. J Neuroinflammation. 20:25. PubMed
  4. Bai Y, et al. 2021. Front Cell Dev Biol. 9:730095. PubMed
  5. Zhang Z, et al. 2021. Exp Dermatol. 30:102. PubMed
  6. Singhal P, et al. 2016. Proc Natl Acad Sci U S A. 113: 122 - 127. PubMed
  7. Julien A, et al. 2020. Stem Cell Reports. 1.288194444. PubMed
  8. Wei H, et al. 2020. Cell Rep. 33:108252. PubMed
RRID
AB_10897106 (BioLegend Cat. No. 124009)
AB_10897106 (BioLegend Cat. No. 124010)

Antigen Details

Structure
The receptor tyrosine kinase (RTK) family
Distribution

Endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes

Cell Type
Endothelial cells, Epithelial cells, T cells
Biology Area
Angiogenesis, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Fathers KE, et al. 2005. Am. J. Pathol. 167:1753.
2. Yano M, et al. 1997. Blood 89:431726.
3. Kolatsi-Joannou M, et al. 2001. Dev. Dyn. 222:1206.

Gene ID
21687 View all products for this Gene ID
UniProt
View information about CD202b on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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