APC Anti-Rat NKG2A/C/E Antibody anti-NKG2A/C/E

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Clone: WEN28 (See other available formats)
Regulatory Status: RUO
Other Names: KLRC1, Killer Cell Lectin Like Receptor C1, KLRC2, Killer Cell Lectin Like Receptor C2, KLRC3, Killer Cell Lectin Like Receptor C3
Isotype: Mouse IgG1, κ
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Product Citations: publications

WEN28_APC_NKG2A-C-E_Antibody_040518 — Rat splenocytes were stained with anti-rat NKG2A/C/E APC (clone WEN28, left) or mouse IgG1, κ isotype control APC (right), followed by anti-rat CD161 FITC.

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250703

25 µg

91€

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250704

100 µg

190€

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Description

The NKG2 molecules are a family of lectin-like receptors that form heterodimers with CD94. NKG2/CD94 heterodimer are primarily expressed on NK cells, and a subset of CD8⁺ T cells. Studies of CD94/NKG2 heterodimers on NK cells have demonstrated that the NKG2 components transduce signals after ligand binding. NKG2A transduces inhibitory signals, while NKG2C and NKG2E transduce activating signals.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant rat NKG2A-Fc fusion protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2728227 (BioLegend Cat. No. 250703)
AB_2728227 (BioLegend Cat. No. 250704)

Antigen Details

Structure: Type II transmembrane protein
Distribution: NK cells, a subset of CD8⁺ T-lymphocytes.
Function: Signal transduction, Receptor for non-classical MHC Class I molecules
Interaction: DAP10, DAP12, CD94
Ligand/Receptor: Non-classical MHC Class I glycoproteins
Cell Type: NK cells, T cells
Biology Area: Immunology
Molecular Family: MHC Antigens
Antigen References: Berg SF, et al. 1998. Eur J Immunol, 28:444.

Vance RE, et al. 1999. J Exp Med. 190(12).

Vance RE, et al. 1998. J Exp Med. 188(10).

Flornes LM, et al. 2010, Immunogenetics, 62:521

Dissen E, et al. 2008. Semin Immunol. 20:369
Gene ID: 29683 View all products for this Gene ID 29684 View all products for this Gene ID 500338 View all products for this Gene ID
UniProt: View information about NKG2A on UniProt.org

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Related Protocols

Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All NKG2A/C/E Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-rat NKG2A/C/E	WEN28	FC
APC anti-rat NKG2A/C/E	WEN28	FC
PE anti-rat NKG2A/C/E	WEN28	FC

Certificate of Analysis

Go To Top Version: 0 Revision Date: 04/05/2018

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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