- Clone
- 14C2A07 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CLEC15A, MAFA-L, MAFA-2F1, MAFA-LIKE, 2F1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
368625 | 25 tests | 140€ |
Killer cell lectin-like receptor subfamily G member (KLRG1) is a 30 kD, type II membrane glycoprotein with one C-type lectin domain and one immunoreceptor tyrosine-based inhibitory motif (ITIM). KLRG1 is expressed by subsets of natural killer cells (NKs) and effector and memory T cells. It inhibits cell activation and proliferation and is also a marker of T cell senescence. The binding of KLRG1 to E-, N-, or R- cadherins blocks phosphorylation of AKT and increases the expression of cell cycle inhibitors.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human KLRG1-transfected cells.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 605™ under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Brilliant Violet 605™ excites at 405 nm and emits at 603 nm. The bandpass filter 610/20 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 605™ is a trademark of Sirigen Group Ltd.
Learn more about Brilliant Violet™.
This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents. - Excitation Laser
-
Violet Laser (405 nm)
- RRID
-
AB_3662365 (BioLegend Cat. No. 368625)
Antigen Details
- Structure
- Type II membrane glycoprotein, one C-type lectin domain, one ITIM, 30 kD.
- Distribution
-
Subsets of natural killer cells, effector and memory T cells.
- Function
- Inhibits cell activation and proliferation
- Interaction
- AKT.
- Ligand/Receptor
- E-, N-, R- cadherins.
- Cell Type
- NK cells, T cells
- Biology Area
- Immunology
- Antigen References
-
1. Shi L, et al. 2014. J. Immunol. 192:649.
- Gene ID
- 10219 View all products for this Gene ID
- UniProt
- View information about KLRG1 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All KLRG1 (MAFA) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human KLRG1 (MAFA) | 14C2A07 | FC |
Brilliant Violet 421™ anti-human KLRG1 (MAFA) | 14C2A07 | FC |
APC anti-human KLRG1 (MAFA) | 14C2A07 | FC |
PerCP/Cyanine5.5 anti-human KLRG1 (MAFA) | 14C2A07 | FC |
PE anti-human KLRG1 (MAFA) | 14C2A07 | FC |
PE/Dazzle™ 594 anti-human KLRG1 (MAFA) | 14C2A07 | FC |
PE/Cyanine7 anti-human KLRG1 (MAFA) | 14C2A07 | FC |
Alexa Fluor® 488 anti-human KLRG1 (MAFA) Antibody | 14C2A07 | FC |
Alexa Fluor® 647 anti-human KLRG1 (MAFA) | 14C2A07 | FC |
APC/Fire™ 810 anti-human KLRG1 (MAFA) | 14C2A07 | FC |
Brilliant Violet 785™ anti-human KLRG1 (MAFA) | 14C2A07 | FC |
APC/Fire™ 750 anti-human KLRG1 (MAFA) | 14C2A07 | FC |
Spark Red™ 718 anti-human KLRG1 (MAFA) (Flexi-Fluor™) | 14C2A07 | FC |
Brilliant Violet 605™ anti-human KLRG1 (MAFA) | 14C2A07 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with purifie... -
Brilliant Violet 421™ anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with CD56 PE... -
APC anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with CD56 PE... -
PerCP/Cyanine5.5 anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with CD56 AP... -
PE anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with CD56 AP... -
PE/Dazzle™ 594 anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with CD56 AP... -
PE/Cyanine7 anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with CD56 Pa... -
Alexa Fluor® 488 anti-human KLRG1 (MAFA) Antibody
Human peripheral blood lymphocytes were stained with CD56 AP... -
Alexa Fluor® 647 anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with anti-hu... -
APC/Fire™ 810 anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with anti-hu... -
Brilliant Violet 785™ anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with anti-hu... -
APC/Fire™ 750 anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with anti-hu... -
Spark Red™ 718 anti-human KLRG1 (MAFA) (Flexi-Fluor™)
-
Brilliant Violet 605™ anti-human KLRG1 (MAFA)
Human peripheral blood lymphocytes were stained with anti-hu...
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