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PE anti-human CD110 Antibody

Pricing & Availability
Clone
S16017A (See other available formats)
Regulatory Status
RUO
Other Names
TPOR, c-MPL, MPLV
Isotype
Mouse IgG2b, κ
Ave. Rating
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Product Citations
publications
S16017A_PE_CD110_Antibody_042018
Resting human platelets were stained with PE anti-human CD110 (clone S16017A; filled histogram) or with PE mouse IgG2b, κ isotype control (open histogram).
  • S16017A_PE_CD110_Antibody_042018
    Resting human platelets were stained with PE anti-human CD110 (clone S16017A; filled histogram) or with PE mouse IgG2b, κ isotype control (open histogram).
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393803 25 tests 132€
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393804 100 tests 283€
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Description

CD110 is a type I transmembrane glycoprotein which functions as a receptor for thrombopoietin; binding causes the proliferation and differentiation of megakaroyocytes in addition to the production of platelets and protection of stem cells from apoptosis. CD110 is primarily expressed on hematopoietic stem cells, hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human CD110 transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2734475 (BioLegend Cat. No. 393803)
AB_2734475 (BioLegend Cat. No. 393804)

Antigen Details

Structure
Type I transmembrane glycoprotein
Distribution

Hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.

Function
Megakaryocytopoiesis and platelet formation
Interaction
THPO, ATXN2L, JAK2
Ligand/Receptor
Thrombopoietin
Cell Type
Hematopoietic stem and progenitors, Platelets, Megakaryocytes
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References
  1. Ninos JM, et al. 2006. J. Transl. Med. 16:4-9.
  2. Broudy VC, et al. 1996. Blood. 88:2026-32.
  3. Wang X, et al. 2016. Blood. 127:3398-409.
Gene ID
4352 View all products for this Gene ID
UniProt
View information about CD110 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 04/23/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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