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PE anti-human CD238/KEL Recombinant Antibody

Pricing & Availability
Clone
QA20A42 (See other available formats)
Regulatory Status
RUO
Other Names
Kell blood group glycoprotein, Kell blood group antigen Kpbc, KELL and ECE3
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
QA20A42_PE_CD238_Antibody_021823
Human peripheral red blood cells were stained with anti-human CD238/KEL recombinant (clone QA20A42) PE (left) or mouse IgG1, κ PE isotype control (right). Cells were costained with anti-human CD235 APC.
  • QA20A42_PE_CD238_Antibody_021823
    Human peripheral red blood cells were stained with anti-human CD238/KEL recombinant (clone QA20A42) PE (left) or mouse IgG1, κ PE isotype control (right). Cells were costained with anti-human CD235 APC.
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378703 25 tests 156€
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378704 100 tests 316€
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Description

QA20A42 recognizes human CD238 also known as the kell blood group antigen Kpbc, KELL and ECE3. CD238 is an approximately 115 kD type II transmembrane glycoprotein that is encoded by the KEL gene. CD238 is expressed on erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues, including testis, heart, brain and skeletal muscle. CD238 functions as a zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a vasoconstrictor. Decreased expression of CD238 is associated with the McLeod phenotype as a consequence of losing XK protein expression.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Clone QA20A42 can completely block the binding of positive clone to target cells.

RRID
AB_2936750 (BioLegend Cat. No. 378703)
AB_2936750 (BioLegend Cat. No. 378704)

Antigen Details

Structure
Type II transmembrane glycoprotein 93-115 kD
Distribution

Erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues

Function
Zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a vasoconstrictor. Blood transfusions and also specific autoimmune diseases related to Kell antigen recognition.
Ligand/Receptor
Laminin α5
Cell Type
Embryonic Stem Cells, Erythrocytes
Biology Area
Immunology
Molecular Family
Blood Group Markers, CD Molecules
Antigen References
  1. Daniels G. 2009. Hum Genet. 126:729-42.
  2. Denomme GA. 2015. Immunohematology. 31:14-9.

 

Gene ID
3792 View all products for this Gene ID
UniProt
View information about CD238/KEL on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 02/17/2023

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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