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PE anti-human TCR Vδ2 Antibody

Pricing & Availability
Clone
B6 (See other available formats)
Regulatory Status
RUO
Other Names
T cell receptor V δ 2, TRDV2, TCRDV102S1
Isotype
Mouse IgG1, κ
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Product Citations
publications
B6_PE_061708.jpg
Human peripheral blood lymphocytes stained with CD3 (UCHT1) APC and B6 PE
  • B6_PE_061708.jpg
    Human peripheral blood lymphocytes stained with CD3 (UCHT1) APC and B6 PE
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Cat # Size Price Quantity Check Availability Save
331407 25 tests 98€
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331408 100 tests 215€
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Description

The Vδ2 TCR is a variant of the TCR δ chain expressed on a subset of γ/δ T cells. Vγ9Vδ2 T lymphocytes, a major γ/δ T cell subset in humans, recognize phosphoantigens, certain tumor cells, and cells treated with aminobisphosphonates. This cell population displays cytolytic activity against various tumor cells. The γ/δ TCR is an heterodimeric TCR complex composed of covalently bound γ and δ chains involved in antigen recognition and the non-covalently associated monomorphic proteins CD3δ, γ, ε, and ζ chains.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
Chimpanzee
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Rojas RE, et al. 2005. J. Infect. Dis. 192:1806.
  2. Correia DV, et al. 2011. Blood 118:992. (FC) PubMed
Product Citations
  1. Ogishi M, et al. 2023. J Exp Med. 220: . PubMed
  2. Mayassi T, et al. 2019. Cell. 176:967. PubMed
  3. Zhan Y, et al. 2021. JCI Insight. 6:. PubMed
  4. McCarthy N, et al. 2013. J Immunol. 191:2752. PubMed
  5. Fisher J, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.03.002. PubMed
  6. López M, et al. 2014. Cell Immunol. 288:47. PubMed
  7. Meraviglia S, et al. 2017. Oncoimmunology. 6:e1347742. PubMed
  8. Hunter S, et al. 2018. J Hepatol. 69:654. PubMed
  9. Yin S, et al. 2015. Sci Rep. 5: 14432. PubMed
  10. Correia DV, et al. 2011. Blood. 118:992. PubMed
  11. Frasca D, et al. 2018. PLoS One. 13:e0197472. PubMed
  12. Lo Presti E, et al. 2020. J Leukoc Biol. 108:749. PubMed
  13. Ribot J, et al. 2014. J Immunol. 192:2237. PubMed
  14. Siegers G, et al. 2011. PLoS One. 6:e16700. PubMed
RRID
AB_1089233 (BioLegend Cat. No. 331407)
AB_1089233 (BioLegend Cat. No. 331408)

Antigen Details

Structure
Ig superfamily member, TCR γ/δ with CD3 forms the CD3/TCR complex
Distribution

Expressed on majority of peripheral γ/δT cells

Function
Antigen recognition, T cell activation
Ligand/Receptor
Peptide bound to MHC
Cell Type
T cells
Biology Area
Adaptive Immunity, Immunology
Molecular Family
TCRs
Antigen References

1. Scotet E, et al. 2005. Immunity 22:71.
2. Rincon-Orozco B, et al. 2005. J. Immunol. 175:2144.

Gene ID
6964 View all products for this Gene ID
UniProt
View information about TCR Vdelta2 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 03/21/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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