- Clone
- E6D7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Apolipoprotein E, apolipoprotein E3, AD2, LDLCQ5, LPG, ApoE
- Previously
-
Signet Catalog# 9750-02
Signet Catalog# 9750-05
Signet Catalog# 9750-10
Covance Catalog# SIG-39750
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
803403 | 1 mL | 1399€ | ||||
803401 | 200 µL | 449€ |
Apo-E is a class of apolipoprotein primarily synthesized in the liver, but is also found in other tissues such as brain, kidneys, and spleen. Apo-E is a protein component of serum chylomicron and lipoprotein particles, playing essential roles in cholesterol transportation, homeostasis, and metabolism. The expression of Apo-E is induced by cholesterol-rich diets and hyperlipoproteinemia. In the central nervous system, Apo-E is produced by astrocytes and microglia. The Apo-E-containing lipoprotein particles play important functions in brain injury repair, neurogenesis, and synaptic plasticity. Apo-E has been found to be involved in the regulation of amyloid-β aggregation and clearance. Genetic polymorphisms of Apo-E are associated with neuron degenerative disorders including Alzheimer's disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- This antibody was raised against a synthetic peptide corresponding to amino acids surrounding the polymorphic amino acid position 158 of Apo-E.
- Formulation
- Phosphate-buffered solution (no preservatives or carrier proteins).
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 1 mg/ml
- Storage & Handling
- This antibody should be handled aseptically as it is free of preservatives such as Sodium Azide. Store this antibody undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check the vial label or CoA to find the proper storage conditions.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 - 5.0 µg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
This antibody is effective in immunoblotting (WB).
Clone E6D7 recognizes the E2, E3, and E4 isoforms of apolipoprotein E. -
Application References
(PubMed link indicates BioLegend citation) -
- Munoz DG, Feldman H. 2000. CMAJ. 162(1):65-72.
- Hagberg JM, et al. 2000. Physiol Genomics 4(2):101-108.
- Saunders AM. 2000. J. Neuropathol. Exp. Neurol. 59(9):751-8.
- Golabek AA, et al. 2000. Biophys. J. 79(2):1008-15.
- Zunarelli E, et al. 2000. Breast Cancer Res. Treat. 63(3):193-8.
- Zunarelli E, et al. 2000. Clin. Neuropathol. 19(1):1-6.
- Tomiyama T, et al. 1999. Cell Mol. Life Sci. 56(3-4):268-79.
- Golabek AA., et al. 1999. J. Biol. Chem. 271(18):10602-6.
- RRID
-
AB_2564663 (BioLegend Cat. No. 803403)
AB_2564663 (BioLegend Cat. No. 803401)
Antigen Details
- Biology Area
- Cell Biology, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance
- Molecular Family
- Apolipoproteins
- Gene ID
- 348 View all products for this Gene ID
- UniProt
- View information about Apo E on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Apo E Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Apo E | E6D7 | WB |
PE anti-Apo E | E6D7 | ICFC |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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