- Clone
- 8E5 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- DSG2
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
869401 | 25 µg | 85€ | ||||
869402 | 100 µg | 221€ |
Desmoglein 2 (DSG2) is a calcium-binding adhesion molecule that is highly expressed in epithelial cells and cardiomyocytes in vertebrates. DSG2 mainly locates to the intracellular adhesive junction called desmosome, which is a structure that functions in cell-to-cell adhesion. Clinically, mutations in DSG2 are mostly linked to cardiomyopathy. A recent GWAS study has shown that DSG2 is 1 of the 20 genetic risk factors that are associated with Alzheimer's disease.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 10 µg/ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2814633 (BioLegend Cat. No. 869401)
AB_2814633 (BioLegend Cat. No. 869402)
Antigen Details
- Structure
- DSG2 is a 1118 amino acid protein with predicted molecular mass of ~122 kD and observed molecular mass of ~150 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Plasma membrane
- Function
- DSG2 is localized to desmosomes and functions in cell-to-cell adhesion.
- Interaction
- DSG2 is an integral component of desmosomes.
- Cell Type
- Epithelial cells
- Biology Area
- Cell Adhesion, Neurodegeneration, Neuroinflammation, Synaptic Biology
- Molecular Family
- Adhesion Molecules
- Antigen References
-
- Kim JH. 2018. Dement Neurocogn Disord. 10.12779/dnd.2018.17.4.131.
- Harrison OJ, et al. 2016. Proc. Natl. Acad. Sci U S A. 113:7160-5.
- Gene ID
- 1829 View all products for this Gene ID
- UniProt
- View information about Desmoglein 2 on UniProt.org
Related FAQs
Other Formats
View All Desmoglein 2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Desmoglein 2 | 8E5 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Desmoglein 2
Western blot of purified anti-Desmoglein 2 antibody (clone 8...
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