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Purified anti-human ACE2 Antibody

Pricing & Availability
Clone
4G8C11 (See other available formats)
Regulatory Status
RUO
Other Names
Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACE-2, ACEH
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
4G8C11_PURE_ACE2_060324
Human ACE2 transfected SW480 cells (human colon adenocarcinoma cell line) were stained with purified anti-human ACE2 (clone S22015B) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by goat anti-mouse IgG PE.
  • 4G8C11_PURE_ACE2_060324
    Human ACE2 transfected SW480 cells (human colon adenocarcinoma cell line) were stained with purified anti-human ACE2 (clone S22015B) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by goat anti-mouse IgG PE.
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342752 100 µg 252€
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Description

Angiotensin-converting enzyme 2 (ACE2) is a type one transmembrane protein, which shares approximately 60% homology with ACE. The predicted human ACE2 protein sequence consists of 805 amino acids, including an N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE2 catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction. ACE2 has been shown to be a functional receptor for the spike glycoprotein of the human coronavirus, HCoV-NL63, and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2. Based on recent single-cell RNA sequencing database, high ACE2 RNA expression was identified in the lung, esophagus, kidney, intestine, bile duct, heart, testis, endothelial cells, and vascular smooth muscle cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_3106182 (BioLegend Cat. No. 342752)

Antigen Details

Structure
Type one transmemberance protein. Catalytic domain.
Distribution

Type II alveolar cells (AT2) of lung, esophagus upper and stratified epithelial cells, kidney proximal tubule cells, enterocytes in ileum and colon, cholangiocyte in bile duct, myocardial cells in heart, endothelium and vascular smooth muscle cells

Function
Catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7 involved in vasoconstriction
Cell Type
Epithelial cells
Biology Area
Cell Adhesion, COVID-19
Molecular Family
Adhesion Molecules
Antigen References
  1. South AM, et al. 2020. Nat Rev Nephrol. 16:305-307.
  2. Hoffmann M, et al. 2020. Cell. 181:271-280.
  3. Sungnak W, et al. 2020. Nat Med. 26:681-687.
  4. Li W, et al. 2003. Nature. 426:450-4.
  5. Heurich A, et al. 2014. J Virol. 88:1293-307.
  6. Hamming I, et al. 2004. J Pathol. 203:631-7.
Gene ID
59272 View all products for this Gene ID
UniProt
View information about ACE2 on UniProt.org
Go To Top Version: 1    Revision Date: 04/18/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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