- Clone
- TLR1.136 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD281, TLR1, TLR-1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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334502 | 100 µg | 207€ |
Toll-like receptors (TLRs) are type I transmembrane signaling receptors characterized by containing leucine-rich repeats (LRR) extracellular domain and IL-1 receptor like intracellular domain. TLRs are responsible for recognizing pathogen-associated molecule patterns (PAMPs). They are primary sensors of both innate and adaptive immune systems. To date a total of 12 TLRs have been indentified. Toll-like receptor 1 (TLR1), known as CD281, is expressed on monocytes/macrophages, dendritic cells, and granulocytes and some lymphocytes at low levels. By association with TLR2, TLR1 is a coreceptor involved in the response to diverse set of pathogens, such as triacylated lipopeptidess (but not diacylated lipopeptides), peptidoglycans, lipoteichoic acid.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TLR1 transfected Ba/F3
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IP, ICC - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Other reported applications include immunoprecipitation1 and immunofluorescence1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Nakao Y, et al. 2005. J. Immunol. 174:1566. (BA IP FC IF) PubMed
- RRID
-
AB_1186023 (BioLegend Cat. No. 334502)
Antigen Details
- Structure
- Type I transmembrane protein characterized by containing leucine-rich repeats (LRR) extracellular domain and IL-1 receptor like intracellular domain, heterodimer with TLR2
- Distribution
-
Monocytes/macrophages, dendritic cells
- Function
- Coreceptor with TLR2 to activate innate host defense against diverse set of pathogens
- Ligand/Receptor
- Microbial lipoproteins, peptidoglycans, lipoteichoic acid
- Cell Type
- Dendritic cells, Macrophages, Monocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
-
1. Hoebe K, et al. 2005. Nature 433:523.
2. Sandor F, et al. 2003. J. Cell Biol. 162:1099.
3. Takeuchi O, et al. 2002. J. Immunol. 169:10.
4. Wyllie D, et al. 2000. J. Immunol. 165:7125.
5. Buwitt-Beckmann U, et al. 2006. J. Biol. Chem. 281:9049. - Gene ID
- 7096 View all products for this Gene ID
- UniProt
- View information about CD281 on UniProt.org
Related FAQs
Other Formats
View All CD281 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD281 (TLR1) | TLR1.136 | FC,IP,ICC |
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Purified anti-human CD281 (TLR1)
Human peripheral blood monocytes stained with purified TLR1....
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