- Clone
- A20115H (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Beta-1B-Glycoprotein 3 4, Epididymis Secretory Sperm Binding Protein
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
381102 | 100 µg | 340€ |
Hemopexin, also known as beta-1B-glycoprotein, haemopexin, Hpx, and Hx, is a glycoprotein that has a molecular mass of approximately 63 kD and belongs to the hemopexin family of proteins. Hemopexin is the plasma protein with the highest binding affinity for heme. When oxidized, hemoglobin that circulates alone in the plasma (also known as free hemoglobin) turns into methemoglobin. Methemoglobin then further dissociates into free heme alongside the globin chain. When further oxidization occurs, the free heme will turn into free met-heme. This will cause the hemopexin to bind to the free met-heme, forming a met-heme and hemopexin complex until it reaches a receptor on hepatocytes or macrophages within the spleen, liver, and bone marrow. Evidence suggests that brain and blood iron homeostasis is perturbed in Alzheimer’s diseases. Deficiency of iron loading onto its major transporter protein, transferrin, was observed in Alzheimer’s, which suggests further examination of peripheral iron/heme metabolism.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2927842 (BioLegend Cat. No. 381102)
Antigen Details
- Structure
- 462 amino acid protein with a molecular mass of 63 kD
- Distribution
-
Tissue Distribution: liver
Cellular Distribution: plasma membrane, nucleus, cytosol, lysosome, and endosome - Function
- Binds to free heme in blood vessel for iron homeostasis
- Interaction
- LRP1
- Ligand/Receptor
- Free heme
- Biology Area
- Cell Biology, Cell Death, Neuroscience
- Molecular Family
- APP/β-Amyloid, APP/Aβ Degradation, Apolipoproteins
- Antigen References
-
- Altruda F, et al. 1988. J Mol Evol. 27:102-8.
- Watanabe J, et al. 2009. J Biol Chem. 284:18292-301.
- Yang Z, et al. 2010. J Biol Chem. 285:28874-82.
- Gene ID
- 3263 View all products for this Gene ID
- UniProt
- View information about Hemopexin on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Hemopexin Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human Hemopexin (HPX) | A20115H | IHC-P |
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Purified anti-human Hemopexin (HPX)
Human paraffin-embedded liver tissue slices were prepared wi...
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