Purified anti-mouse TCR Vgamma1.1/Cr4 Antibody anti-TCR V gamma1.1

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Clone: 2.11 (See other available formats)
Regulatory Status: RUO
Other Names: T cell receptor Vgamma 1.1, TCR Vγ1 (Tonegawa nomenclature), TCR Cr4, TRGV1, GV5S1
Isotype: Armenian Hamster IgG
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Product Citations: publications

2.11_FITC_1_113010 — C57BL/6 mouse lymph node cells were stained with anti-mouse TCR γ/δ (clone GL3) APC and anti-mouse TCR Vγ1.1 (clone 2.11) FITC (top) or Armenian hamster IgG FITC isotype control (bottom).

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141102

100 µg

165€

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Description

T cell receptor (TCR) is a heterodimer consisting of an α and β chain (TCR α/β) or a γ and δ chain (TCR γ/δ). TCR associates with CD3 to form a CD3/TCR complex. The CD3/TCR plays a key role in antigen recognition, signal transduction, and T cell activation. TCR Vγ1.1 (Garman nomenclature) is also called TCR Vγ1 (Tonegawa nomenclature). The Vγ1 gene almost exclusively rearranges to the Jγ4-Cγ4 gene. Vγ1- Jγ4-Cγ4 expressing cells constitute a major population of γ/δ T cells in the thymus and peripheral lymphoid organs in adult mice, but they are only composed of a minor population of γ/δ T cells during fetal and early postnatal life. Vγ1 T cell development can happen in thymus-dependent and thymus-independent manners. Further studies have shown that the antibody 2.11 recognizes an epitope located in the Cr4 domain.

Several TCR γ and δ chain nomenclature systems exist. In order to consolidate the various nomenclature systems, we have created charts for corresponding names across some of the most popular naming methods. Click here to see charts.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Armenian Hamster
Immunogen: T3.13.1 T-cell hybridoma cell line
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
IP - Reported in the literature, not verified in house
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Additional reported applications (for the relevant formats) include: immunoprecipitation¹.
RRID: AB_10693548 (BioLegend Cat. No. 141102)

Antigen Details

Structure: Ig superfamily
Distribution: Subset of γ/δ T-cells
Function: Antigen recognition
Ligand/Receptor: Antigen
Cell Type: T cells
Biology Area: Adaptive Immunity, Immunology
Molecular Family: TCRs
Antigen References: 1. Pereira P, et al. 1995. J. Exp. Med. 182:1921.
2. Grigoriadou K, et al. 2002. J. Immunol. 169:3736.
Gene ID: 110067 View all products for this Gene ID
UniProt: View information about TCR Vgamma1.1/Cr4 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All TCR Vγ1.1/Cr4 Reagents Request Custom Conjugation

Description	Clone	Applications
FITC anti-mouse TCR Vγ1.1/Cr4	2.11	FC
PE anti-mouse TCR Vγ1.1/Cr4	2.11	FC
Purified anti-mouse TCR Vγ1.1/Cr4	2.11	FC,IP
APC anti-mouse TCR Vγ1.1/Cr4	2.11	FC
Pacific Blue™ anti-mouse TCR Vγ1.1/Cr4	2.11	FC
PerCP/Cyanine5.5 anti-mouse TCR Vγ1.1/Cr4	2.11	FC
TotalSeq™-C0209 anti-mouse TCR Vγ1.1/Cr4	2.11	PG
Brilliant Violet 421™ anti-mouse TCR Vγ1.1/Cr4	2.11	FC
Spark Red™ 718 anti-mouse TCR Vγ1.1/Cr4 (Flexi-Fluor™)	2.11	FC
Spark Blue™ 574 anti-mouse TCR Vγ1.1/Cr4 (Flexi-Fluor™)	2.11	FC
Spark Blue™ 550 anti-mouse TCR Vγ1.1/Cr4 (Flexi-Fluor™)	2.11	FC

Certificate of Analysis

Go To Top Version: 2 Revision Date: 11/08/2023

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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