Purified anti-mouse TSLPR TSLP-R Antibody anti-TSLPR

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Clone: 22H9 (See other available formats)
Regulatory Status: RUO
Other Names: Thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, CRLF2, IL-XR, TSLP-R
Isotype: Rat IgG2a, κ
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22H9_PURE_TSLPR_Antibody_1_063016 — C57BL/6 bone marrow cells were stained with CD20 Alexa Fluor® 647 and purified TSLPR (clone 22H9) (top) or purified rat IgG2a, κ isotype control (bottom), followed by anti-rat IgG2a PE. Data shown is gated on lymphoid population.

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151802

100 µg

175€

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Description

TSLP-R, also known as the thymic stromal lymphopoietin protein receptor, cytokine receptor-like 2, CRL2, and IL-XR, is a 40kD type I membrane receptor that forms a functional heterodimeric complex with IL-7R and binds with TSLP. TSLPR is required for proper protein folding and a box1 motif important for association with the JAKs. TSLP-R is expressed in myeloid cells, dendritic cells, B cells and activated monocytes. It is weakly expressed in T cells. Expression has also been reported in heart, skeletal, muscle, and kidney tissues. Ligand receptor interactions have been implicated in the development of the hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergy diseases.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: TSLP Receptor Protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2616861 (BioLegend Cat. No. 151802)

Antigen Details

Structure: Type I membrane receptor, forms functional heterodimeric complex with IL-7R to bind TSLP. Contains WSXWS motif required for proper protein folding and a box1 motif that is important for association with the JAKs.
Distribution: Expressed preferentially in myeloid cells including dendritic cells, B cells, activated monocytes, weakly expressed in T cells. Also expressed in heart, skeletal, muscle, and kidney cells.
Function: Binds to TSLP to stimulate cell proliferation.
Ligand/Receptor: TSLP.
Cell Type: Dendritic cells, B cells, Monocytes
Biology Area: Immunology
Molecular Family: Cytokine/Chemokine Receptors
Antigen References: 1. Reche PA, et al. 2001. J. Immunol. 167:336.
2. Tonozuka Y, et al. 2001. Cytogenet. Cell Genet. 93:23.
3. Zhang W, et al. 2001. Biochem. Biophys. Res. Commun. 281:878.
4. Wang YH, et al. 2006. Immunity 24:827.
Gene ID: 57914 View all products for this Gene ID
UniProt: View information about TSLPR on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All TSLPR (TSLP-R) Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-mouse TSLPR (TSLP-R)	22H9	FC
Biotin anti-mouse TSLPR (TSLP-R)	22H9	FC
APC anti-mouse TSLPR (TSLP-R)	22H9	FC
Brilliant Violet 421™ anti-mouse TSLPR (TSLP-R)	22H9	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 06/30/2016

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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