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APC anti-human CD132 (common γ chain) Antibody

Pricing & Availability
Clone
TUGh4 (See other available formats)
Regulatory Status
RUO
Workshop
VI C-89
Other Names
Common γ chain, γc, IL-2 receptor γ subunit
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
TUGh4_APC_011409.jpg
Human peripheral blood lymphocytes stained with TUGh4 APC
  • TUGh4_APC_011409.jpg
    Human peripheral blood lymphocytes stained with TUGh4 APC
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338607 25 tests 114€
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338608 100 tests 266€
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Description

CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, also known as common γ chain (γc), or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Rat
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Itano M, et al. 1996. J. Exp. Med. 178:389
  2. Kondo M, et al. 1993. Science 262:1874
Product Citations
  1. Market M, et al. 2022. Int J Mol Sci. 23: . PubMed
  2. Wefers C, et al. 2018. Int J Mol Sci. 19. PubMed
  3. Rajawat YS, et al. 2021. Hum Gene Ther. 32:113. PubMed
  4. Market M, et al. 2020. Front Immunol. 1.127083333. PubMed
  5. Kumar A, et al. 2021. STAR Protoc. 2:100874. PubMed
  6. Matsubara Y, et al. 2014. Sci Rep. 4:5043. PubMed
  7. Massoud R, et al. 2015. Proc Natl Acad Sci U S A. 112: 11030-11035. PubMed
  8. Farhat AM, et al. 2021. Cell Reports. 35(4):109044. PubMed
  9. Hodge L, et al. 2012. Blood. 120:3774. PubMed
  10. Jiang J, et al. 2016. Sci Rep. 6: 32320. PubMed
RRID
AB_2123584 (BioLegend Cat. No. 338607)
AB_2123584 (BioLegend Cat. No. 338608)

Antigen Details

Structure
Type I transmembrane glycoprotein, Ig superfamily 64-70 kD
Distribution

T cells, B cells, NK, monocytes, granulocytes

Ligand/Receptor
Component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21
Cell Type
B cells, Granulocytes, Monocytes, NK cells, T cells
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors
Antigen References

1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
2. Nakarai T, et al. 1994. J. Exp. Med. 180:241
3. Kawahara A, et al. 1995. Proc. Natl. Acad. Sci. USA. 92:8724
4. Habib T, et al. 2002. Biochemistry. 41:8725
5. Matthews DJ, et al. 1995. Blood 85:38

Gene ID
3561 View all products for this Gene ID
UniProt
View information about CD132 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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